Department of Chemical Engineering, Hanyang University, Seoul 133-791, South Korea.
J Chromatogr A. 2014 May 9;1341:8-14. doi: 10.1016/j.chroma.2014.03.038. Epub 2014 Mar 18.
The three-zone simulated moving bed (SMB) chromatographic process for separation of succinic acid and lactic acid, which has been developed previously, was based on a classical port-location arrangement (desorbent→extract→feed→raffinate) and a classical feeding mode (full-feeding). To improve the performance of the three-zone SMB process, it is worth utilizing the strategy of either a port-location rearrangement (desorbent→feed→raffinate→extract) or a partial-feeding. To investigate which of the two strategies is more effective, the three-zone SMBs based on the port-location rearrangement (PR) and the partial-feeding (PF) were optimized each under equal conditions and then the two strategies were compared in terms of product purities or throughput. The result showed that the PR strategy led to higher purities or higher throughput than the PF strategy in regard to the previously reported three-zone SMB system. To check whether such trend is still valid in other separation systems, the above optimization works were repeated while varying only the selectivity between two feed components. It was confirmed that the PR strategy is definitely superior to the PF strategy. However, such superiority of the PR over the PF strategy is lessened as the selectivity becomes lower. If the selectivity is significantly low, the PR strategy is rather outperformed by the PF strategy.
先前开发的用于分离琥珀酸和乳酸的三区模拟移动床（SMB）色谱过程基于经典的端口位置布置（解吸剂→萃取→进料→萃余物）和经典的进料模式（全进料）。为了提高三区 SMB 过程的性能，值得采用端口位置重新排列（解吸剂→进料→萃余物→萃取）或部分进料的策略。为了研究这两种策略中哪一种更有效，在相同条件下对基于端口位置重新排列（PR）和部分进料（PF）的三区 SMB 进行了优化，然后根据产品纯度或产量对这两种策略进行了比较。结果表明，与之前报道的三区 SMB 系统相比，PR 策略导致更高的纯度或更高的产量。为了检查这种趋势在其他分离系统中是否仍然有效，仅改变两个进料组分之间的选择性，重复了上述优化工作。确认 PR 策略确实优于 PF 策略。然而，随着选择性的降低，PR 策略相对于 PF 策略的优势减小。如果选择性明显较低，则 PR 策略的性能不如 PF 策略。
