Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de Deu, Barcelona, Spain.
Pediatr Infect Dis J. 2012 Jun;31(6):650-3. doi: 10.1097/INF.0b013e31824f25b0.
Seventy-one patients <5 years of age who were hospitalized with invasive pneumococcal disease were studied in the period between August 2008 and December 2009. The purpose was to determine the proportion of episodes that were coinfected with respiratory virus. Viral coinfection was common (44/71; 62%), with rhinovirus and influenza virus being the most frequently detected. Highly invasive serotypes (1, 5, 7F, 14, 19A) were found in 31 of 71 patients, of whom 15 had viral coinfection (15/31; 48%). Viral detection occurred significantly more often in those episodes caused by nonhighly invasive serotypes (29/40; 72%), suggesting that a viral synergism could help those serotypes to make invasiveness more likely.
2008 年 8 月至 2009 年 12 月期间，研究了 71 名 <5 岁因侵袭性肺炎球菌病住院的患者。目的是确定与呼吸道病毒合并感染的病例比例。病毒合并感染很常见（71 例中有 44 例；62%），其中检测到鼻病毒和流感病毒最为常见。在 71 例患者中发现了 31 例高度侵袭性血清型（1、5、7F、14、19A），其中 15 例有病毒合并感染（31 例中有 15 例；48%）。非高度侵袭性血清型引起的感染中病毒检测的发生率明显更高（40 例中有 29 例；72%），这表明病毒协同作用可能有助于这些血清型更易发生侵袭性。
