Institut Universitari Barraquer, Universitat Autònoma de Barcelona, Barcelona, Spain.
Can J Ophthalmol. 2012 Feb;47(1):16-20. doi: 10.1016/j.jcjo.2011.12.008.
To evaluate the efficacy of photodynamic therapy (PDT) for symptomatic circumscribed choroidal hemangioma (CCH).
A retrospective case series analysis through chart review of patients with CCH treated by means of PDT.
Thirteen patients with circumscribed choroidal hemangioma.
Through retrospective charts review, the patients' demographics, clinical features, management, and follow-up data were obtained and analyzed. Outcome measures were change in visual acuity, required sessions, and adjunctive treatments.
Median follow-up was 26 months. Seven patients (54%) underwent only 1 session, 5 patients (38%) 2 sessions, and 1 received 5 sessions and was finally treated with external beam radiotherapy (EBRT). Visual acuity improved by at least 1 line (1-5) in 11 patients and remained stable in 2. Exudative subretinal fluid was completely resolved in 92% of the cases at the last visit. No major local side effects were found.
PDT of CCH can effectively induce tumor regression and resolution of exudative subretinal fluid, improving, or stabilizing vision.
评估光动力疗法（PDT）治疗症状性局限性脉络膜血管瘤（CCH）的疗效。
通过对接受 PDT 治疗的 CCH 患者的图表回顾进行回顾性病例系列分析。
13 名局限性脉络膜血管瘤患者。
通过回顾性图表审查，获取并分析了患者的人口统计学、临床特征、治疗和随访数据。结果测量包括视力变化、所需疗程和辅助治疗。
中位随访时间为 26 个月。7 名患者（54%）仅接受 1 次治疗，5 名患者（38%）接受 2 次治疗，1 名患者接受 5 次治疗，最终接受外照射放疗（EBRT）。11 名患者的视力至少提高了 1 行（1-5），2 名患者的视力保持稳定。92%的病例在最后一次就诊时完全消退了渗出性视网膜下液。未发现严重的局部副作用。
PDT 可有效诱导 CCH 肿瘤消退和渗出性视网膜下液吸收，改善或稳定视力。
