运动后血清肌酸激酶：区分生理反应与运动性横纹肌溶解症。
Serum creatine kinase after exercise: drawing the line between physiological response and exertional rhabdomyolysis.
机构信息
Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814, USA.
出版信息
Muscle Nerve. 2012 Mar;45(3):356-62. doi: 10.1002/mus.22317.
INTRODUCTION
In this investigation we assessed the spectrum of creatine kinase (CK) responses in military recruits undergoing basic training.
METHODS
Musculoskeletal examination data, questionnaire findings, and CK levels were obtained from 499 recruits at days 0, 3, 7, and 14 of training. Correlations of CK with ethnicity, age, body mass index, exercise, muscle pain, and climate were obtained.
RESULTS
None of the subjects developed clinical exertional rhabdomyolysis (ER). The mean/median serum CK values were 223/157, 734/478, 1226/567, and 667/486 IU/L at days 0, 3, 7, and 14, respectively, with a wide overall range (34-35,056 IU/L). African-American subjects had higher mean CK levels.
CONCLUSIONS
CK elevations and muscle pain are common during basic training. Widely accepted laboratory diagnostic values for ER are routinely exceeded in this military recruits, suggesting that CK levels >50 times the upper limit of normal are more specific. The findings support using CK as a marker for ER. Normal laboratory reference ranges for CK should be published by ethnicity.
简介
在这项研究中，我们评估了进行基础训练的新兵中肌酸激酶（CK）反应的范围。
方法
在训练的第 0、3、7 和 14 天，从 499 名新兵中获取肌肉骨骼检查数据、问卷调查结果和 CK 水平。获得 CK 与种族、年龄、体重指数、运动、肌肉疼痛和气候的相关性。
结果
没有受试者发生临床性运动性横纹肌溶解症（ER）。血清 CK 值的平均值/中位数在第 0、3、7 和 14 天分别为 223/157、734/478、1226/567 和 667/486IU/L，范围很广（34-35056IU/L）。非裔美国人受试者的 CK 水平较高。
结论
在基础训练期间，CK 升高和肌肉疼痛很常见。在这些新兵中，通常会超过广泛接受的 ER 实验室诊断值，这表明 CK 水平>正常上限的 50 倍更具特异性。这些发现支持将 CK 用作 ER 的标志物。CK 的正常实验室参考范围应按种族公布。
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