Sleep Disorders Unit, Department of Thoracic Medicine, Medical School, University of Crete, Greece.
J Clin Sleep Med. 2012 Feb 15;8(1):21-6. doi: 10.5664/jcsm.1652.
Although the prevalence of obstructive sleep apnea/hypopnea syndrome (OSAHS) is high in patients with acute coronary syndromes (ACS), there is little knowledge about the persistence of OSAHS in ACS patients after the acute event. We aimed to assess the prevalence and time course of OSAHS in patients with ACS during and after the acute cardiac event.
Fifty-two patients with first-ever ACS, underwent attended overnight polysomnography (PSG) in our sleep center on the third day after the acute event. In patients with an apnea hypopnea index (AHI) > 10/h, we performed a follow up PSG 1 and 6 months later.
Twenty-eight patients (54%) had an AHI > 10/h. There was a significant decrease in AHI 1 month after the acute event (13.9 vs. 19.7, p = 0.001), confirming the diagnosis of OSAHS in 22 of 28 patients (79%). At 6-month follow-up, the AHI had decreased further (7.5 vs. 19.7, p < 0.05), and at that time only 6 of the 28 patients (21%) were diagnosed as having OSAHS. Twelve of the 16 current smokers stopped smoking after the acute event.
We have demonstrated a high prevalence of OSAHS in ACS patients, which did not persist 6 months later, indicating that, to some degree, OSAHS may be transient and related with the acute phase of the underlying disease or the reduction in the deleterious smoking habit.
尽管阻塞性睡眠呼吸暂停/低通气综合征（OSAHS）在急性冠状动脉综合征（ACS）患者中的患病率较高，但对于 ACS 患者在急性事件后 OSAHS 的持续存在知之甚少。我们旨在评估 ACS 患者在急性心脏事件期间和之后 OSAHS 的患病率和时间进程。
52 例首次发生 ACS 的患者在急性事件后第 3 天在我们的睡眠中心接受了有监护的夜间多导睡眠图（PSG）检查。在呼吸暂停低通气指数（AHI）> 10/h 的患者中，我们在 1 个月和 6 个月后进行了随访 PSG。
28 例患者（54%）AHI > 10/h。急性事件后 1 个月 AHI 显著下降（13.9 比 19.7，p = 0.001），28 例患者中的 22 例（79%）确诊为 OSAHS。6 个月随访时，AHI 进一步下降（7.5 比 19.7，p < 0.05），此时仅 28 例患者中的 6 例（21%）被诊断为 OSAHS。16 例吸烟者中有 12 例在急性事件后停止吸烟。
我们已经证明 ACS 患者中 OSAHS 的患病率很高，但在 6 个月后没有持续存在，这表明 OSAHS 在某种程度上可能是短暂的，与潜在疾病的急性期或减少有害的吸烟习惯有关。
