Etlik Ihtisas Research and Education Hospital, Ankara, Turkey.
Angiology. 2013 Feb;64(2):131-6. doi: 10.1177/0003319711436247. Epub 2012 Feb 14.
Platelets play a central role in the pathophysiology of coronary artery disease (CAD). Increased mean platelet volume (MPV) is an indicator of platelet function and associated with poor clinical outcome in patients with acute coronary syndrome (ACS). We evaluated the relationship between MPV and severity of CAD in patients with ACS. A total of 395 patients with ACS were included. Severity of CAD was assessed with the Gensini and Syntax scores. High levels of MPV were associated with the Gensini and Syntax scores, number of diseased vessels (>50%), number of critical lesions (>50% and >70%), and noncritical lesions. After multivariate analysis, high levels of MPV were independent predictors of multivessel CAD together with age. In patients with ACS, high MPV levels were associated with severity of CAD. It is possible that MPV can be a helpful marker in patients with CAD for the severity of coronary atherosclerosis.
血小板在冠状动脉疾病（CAD）的病理生理学中起着核心作用。平均血小板体积（MPV）增加是血小板功能的指标，并与急性冠状动脉综合征（ACS）患者的不良临床结局相关。我们评估了 ACS 患者中 MPV 与 CAD 严重程度之间的关系。共纳入 395 例 ACS 患者。CAD 的严重程度采用 Gensini 和 Syntax 评分进行评估。高水平的 MPV 与 Gensini 和 Syntax 评分、病变血管数量（>50%）、临界病变数量（>50%和>70%）和非临界病变相关。多变量分析后，高水平的 MPV 与多支 CAD 以及年龄一起是独立的预测因素。在 ACS 患者中，高 MPV 水平与 CAD 的严重程度相关。MPV 可能是 CAD 患者评估冠状动脉粥样硬化严重程度的有用标志物。
