Faculty of Dentistry, University of Medical Science, La Habana, Cuba.
Clin Oral Implants Res. 2012 May;23(5):542-9. doi: 10.1111/j.1600-0501.2012.02423.x. Epub 2012 Feb 15.
To evaluate the healing at implants with a moderately rough surface placed and stabilized in recipient sites of dimensions deeper and larger than that of the implants to avoid any contact between parent bone and the implant.
MATERIAL & METHODS: In six Labrador dogs, premolars and first molars were extracted bilaterally in the mandible. After 3 months of healing, mucoperiosteal full-thickness flaps were elevated and the premolar area of the alveolar bony crest was selected. Three recipient sites were prepared to place three implants. One implant was used as control. The other two were placed in recipient sites which left a circumferentially and periapical prepared defect of 0.7 mm (small) and 1.2 mm (large), respectively. All implants were stabilized with passive fixation plates to maintain the implants stable and without any contact with the implant bed. After 3 months of submerged healing, the animals were sacrificed. Ground sections were prepared and analyzed histomorphometrically.
The BIC% was 5.3% and 0.3% for implants placed in small and large defect sites, respectively, whereas it was 46.1% for control implants. The differences were statistically significant. The width of the residual defects was 0.4 and 0.5 mm at the small and large defects, respectively. An approximately 0.09 mm layer of dense connective tissue (DCT) rich in fibers and fibroblast-like cells was observed adherent to the implant surfaces. The percentage of implant surface covered by DCT was 92.8% and 95.6% at the small and large defects, respectively.
Osseointegration was observed at the test sites, and the dimensions of the defects influenced the outcomes. However, the degree of osseointegration at both small and large defects was very low compared with the control sites.
评估在深度和宽度大于种植体的受植区中，使用中度粗糙表面的种植体进行植入和稳定，以避免种植体与宿主骨之间的任何接触，从而实现种植体的愈合。
在 6 只 Labrador 狗中，双侧下颌前磨牙和第一磨牙被拔出。愈合 3 个月后，掀起黏骨膜全厚瓣，选择牙槽嵴顶的前磨牙区。制备 3 个受植区以植入 3 个种植体。其中一个种植体作为对照。另外两个种植体分别植入预备出 0.7mm（小）和 1.2mm（大）环形和根尖周预备缺陷的受植区。所有种植体均使用被动固定板固定以保持种植体稳定且与种植床无任何接触。3 个月的埋置愈合后，处死动物。制备磨片并进行组织形态计量学分析。
植入小、大缺陷区的种植体的 BIC%分别为 5.3%和 0.3%，而对照组为 46.1%。差异具有统计学意义。小、大缺陷处的剩余缺陷宽度分别为 0.4mm 和 0.5mm。在种植体表面观察到约 0.09mm 厚的富含纤维和成纤维样细胞的致密结缔组织（DCT）。DCT 覆盖种植体表面的百分比分别为小、大缺陷处的 92.8%和 95.6%。
在试验部位观察到骨整合，且缺陷的尺寸影响了结果。然而，与对照组相比，小、大缺陷处的骨整合程度非常低。
