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骨-种植体间隙大小对界面骨整合的影响：一项体内研究。

Impact of bone-implant gap size on the interfacial osseointegration: an in vivo study.

机构信息

Department of Orthopedics, West China Hospital, Sichuan University, 37# Guoxue Lane, Chengdu Sichuan, 610041, China.

Department of Orthopedics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou Henan, 450052, China.

出版信息

BMC Musculoskelet Disord. 2023 Feb 11;24(1):115. doi: 10.1186/s12891-023-06215-1.

DOI:10.1186/s12891-023-06215-1
PMID:36765314
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9921072/
Abstract

BACKGROUND

The bone-implant gap resulted from morphological mismatch between cervical bony endplates and implant footprint may have adverse impact on bone-implant interfacial osseointegration of cervical disc arthroplasty (CDA). The purpose of the study was to evaluate the impact of bone-implant gap size on the interfacial osseointegration in a rabbit animal model.

METHODS

A series of round-plate implants with different teeth depth (0.5 mm, 1.0 mm, 1.5 mm and 2.0 mm) was specifically designed. A total of 48 New Zealand white rabbits were randomly categorized into four groups by the implants they received (0.5 mm: group A, 1.0 mm: group B, 1.5 mm: group C, 2.0 mm: group D). At 4 and 12 week after surgery, animals were sacrificed. Micro-CT, acid fuchsin and methylene blue staining and hematoxylin and eosin (HE) staining were conducted.

RESULTS

At 4 week and 12 week after surgery, both micro-CT and HE staining showed more new bone formation and larger bone coverage in group A and group B than that in group C and group D. At 12 week, the bone biometric parameters were significantly superior in group C when compared with group D (p < 0.05). At 12 week, hard tissue slicing demonstrated larger portion of direct contact of new bone to the HA coating in group A and group B.

CONCLUSIONS

Bone-implant gap size larger than 1.0 mm negatively affected bone-implant osseointegration between compact bone and HA coated implant surface.

摘要

背景

颈椎骨终板与植入物足迹之间的形态不匹配导致的骨-植入物间隙可能对颈椎间盘置换术（CDA）的骨-植入物界面骨整合产生不利影响。本研究旨在评估兔动物模型中骨-植入物间隙大小对界面骨整合的影响。

方法

专门设计了一系列具有不同齿深（0.5mm、1.0mm、1.5mm 和 2.0mm）的圆板植入物。将 48 只新西兰白兔随机分为四组，根据植入物分为 4 组（0.5mm：A 组、1.0mm：B 组、1.5mm：C 组、2.0mm：D 组）。手术后 4 周和 12 周处死动物。进行微 CT、酸性品红和亚甲蓝染色以及苏木精和伊红（HE）染色。

结果

手术后 4 周和 12 周，微 CT 和 HE 染色均显示 A 组和 B 组的新骨形成和骨覆盖率均大于 C 组和 D 组。12 周时，C 组的骨生物计量学参数明显优于 D 组（p<0.05）。12 周时，硬组织切片显示 A 组和 B 组新骨与 HA 涂层的直接接触部分更大。

结论

大于 1.0mm 的骨-植入物间隙大小会对密质骨和 HA 涂层植入物表面之间的骨-植入物骨整合产生负面影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/9921072/c623ac116bfd/12891_2023_6215_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/9921072/4d237cb359a0/12891_2023_6215_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/9921072/07ade2669521/12891_2023_6215_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/9921072/9f779cc59c12/12891_2023_6215_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/9921072/5399870282fc/12891_2023_6215_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/9921072/c623ac116bfd/12891_2023_6215_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/9921072/4d237cb359a0/12891_2023_6215_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/9921072/07ade2669521/12891_2023_6215_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/9921072/9f779cc59c12/12891_2023_6215_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/9921072/5399870282fc/12891_2023_6215_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03cb/9921072/c623ac116bfd/12891_2023_6215_Fig5_HTML.jpg

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