Tavares Nelson R, Moreira Pedro S, Amaral Teresa F
Faculdade de Ciências da Nutrição e Alimentação, Universidade do Porto, Portugal.
J Nutr Gerontol Geriatr. 2012;31(1):59-70. doi: 10.1080/21551197.2012.647557.
Since information regarding biochemical parameters of riboflavin and folate status is limited in some populations of older adults, a food-frequency questionnaire is often used to estimate riboflavin and folate status. However, the performance of this type of questionnaire among this age group has not been comprehensively evaluated. Thus, we sought to assess riboflavin and folate status in older adults living in Portugal and to validate findings from a semiquantitative food-frequency questionnaire (FFQ), by comparison to these blood measures. We used a cross-sectional study to investigate riboflavin in red blood cells (as Glutathione Reductase Activity Coefficient; EGRAC) and folate in the serum of 88 older persons (66.7% female), aged between 60 and 94 years, recruited from seven adult day care community centers in Porto, Portugal. Forty-six subjects had low EGRAC levels (<1.2), with a group mean concentration of 1.17 and median of 1.10 (range 1.00-2.10). For daily riboflavin dietary intakes from FFQ, the mean was 3.34 mg, the median 3.37 mg, and range 0.66-4.81 mg. The Spearman correlation between these two measures was r = 0.073, (P = 0.497) and Pearson correlation, after adjustment for energy, was r = 0.263, P = 0.013. All participants were above the 7 nmol/L serum folate cut-off for adequacy. Spearman correlation coefficient between serum and FFQ measures was r = -0.10, (P = 0.359), and the Pearson correlation, after adjustment for energy and following log(e) transformation, was r = -0.58, (P = 0.593). Thus riboflavin and folate intakes estimated by FFQ correlated poorly with EGRAC and folate serum values.
由于关于老年人某些群体核黄素和叶酸状况的生化参数信息有限，食物频率问卷常被用于估计核黄素和叶酸状况。然而，这类问卷在该年龄组中的表现尚未得到全面评估。因此，我们试图评估居住在葡萄牙的老年人的核黄素和叶酸状况，并通过与这些血液指标进行比较，验证半定量食物频率问卷（FFQ）的结果。我们采用横断面研究，调查了从葡萄牙波尔图的七个成人日托社区中心招募的88名老年人（66.7%为女性）红细胞中的核黄素（以谷胱甘肽还原酶活性系数；EGRAC表示）和血清中的叶酸，年龄在60至94岁之间。46名受试者的EGRAC水平较低（<1.2），组平均浓度为1.17，中位数为1.10（范围1.00 - 2.10）。对于FFQ得出的每日核黄素膳食摄入量，平均值为3.34毫克，中位数为3.37毫克，范围为0.66 - 4.81毫克。这两种测量方法之间的Spearman相关性为r = 0.073，（P = 0.497），在对能量进行调整后，Pearson相关性为r = 0.263，P = 0.013。所有参与者的血清叶酸充足水平均高于7 nmol/L的临界值。血清和FFQ测量值之间的Spearman相关系数为r = -0.10，（P = 0.359），在对能量进行调整并进行对数变换后，Pearson相关性为r = -0.58，（P = 0.593）。因此，FFQ估计的核黄素和叶酸摄入量与EGRAC和血清叶酸值的相关性较差。
