Ferrari Ariana, de Carvalho Aline Martins, Steluti Josiane, Teixeira Juliana, Marchioni Dirce Maria Lobo, Aguiar Samuel
Department of Pelvic Surgery, A.C. Camargo Cancer Center, Rua Professor Antônio Prudente, 211, Liberdade, São Paulo (SP) CEP 01509-010, Brazil.
Department of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo 715, Consolação, São Paulo (SP) CEP 01246-904, Brazil.
Nutrients. 2015 Jun 2;7(6):4318-35. doi: 10.3390/nu7064318.
To assess the ingestion of folate and nutrients involved in the 1-carbon cycle in non-treated patients with colorectal adenocarcinoma in a reference center for oncology in southeastern Brazil. In total, 195 new cases with colorectal adenocarcinoma completed a clinical evaluation questionnaire and a Food Frequency Questionnaire (FFQ). Blood samples from 161 patients were drawn for the assessment of serum folate. A moderate correlation was found between serum concentrations of folate, folate intake and the dietary folate equivalent (DFE) of synthetic supplements. Mulatto or black male patients with a primary educational level had a higher intake of dietary folate. Of patients obtaining folate from the diet alone or from dietary supplements, 11.00% and 0.10%, respectively, had intake below the recommended level. Of the patients using dietary supplements, 35% to 50% showed high levels of folic acid intake. There was a prevalence of inadequacy for vitamins B2, B6 and B12, ranging from 12.10% to 20.18%, while 13.76% to 22.55% of patients were likely to have adequate choline intake. The considerable percentage of patients with folate intake above the recommended levels deserves attention because of the harmful effects that this nutrient may have in the presence of established neoplastic lesions.
在巴西东南部一家肿瘤学参考中心，评估未经治疗的结肠直肠癌患者对叶酸及参与一碳循环的营养素的摄入量。总共195例新诊断的结肠直肠癌患者完成了一份临床评估问卷和一份食物频率问卷（FFQ）。采集了161例患者的血样以评估血清叶酸水平。血清叶酸浓度、叶酸摄入量与合成补充剂的膳食叶酸当量（DFE）之间存在中度相关性。小学文化程度的混血或黑人男性患者膳食叶酸摄入量较高。仅从饮食中获取叶酸或从膳食补充剂中获取叶酸的患者，分别有11.00%和0.10%的摄入量低于推荐水平。在使用膳食补充剂的患者中，35%至50%的人叶酸摄入量较高。维生素B2、B6和B12摄入不足的患病率在12.10%至20.18%之间，而13.76%至22.55%的患者胆碱摄入量可能充足。由于这种营养素在已确诊的肿瘤病变存在时可能产生有害影响，叶酸摄入量高于推荐水平的患者比例相当值得关注。
