Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
RNA Biol. 2012 Apr;9(4):379-91. doi: 10.4161/rna.19333. Epub 2012 Feb 16.
This review emphasizes the function and regulation of the Csr regulatory system in the human enteropathogen Yersinia pseudotuberculosis and compares its features with the homologous Csr/Rsm systems of related pathogens. The Csr/Rsm systems of eubacteria form a complex regulatory network in which redundant non-translated Csr/Rsm-RNAs bind the RNA-binding protein CsrA/RsmA, thereby preventing its interaction with mRNA targets. The Csr system is controlled by the BarA/UvrY-type of two-component sensor-regulator systems. Apart from that, common or pathogen-specific regulators control the abundance of the Csr components. The coordinate control of virulence factors and infection-linked physiological traits by the Csr/Rsm systems helps the pathogens to adapt individually to rapidly changing conditions to which they are exposed during the different stages of an infection. As Csr/Rsm function is relevant for full virulence, it represents a target suitable for antimicrobial drug development.
本综述强调了人类肠道病原体假结核耶尔森氏菌中 Csr 调控系统的功能和调控作用，并将其特征与相关病原体的同源 Csr/Rsm 系统进行了比较。原核生物的 Csr/Rsm 系统形成了一个复杂的调控网络，其中冗余的非翻译 Csr/Rsm-RNAs 结合 RNA 结合蛋白 CsrA/RsmA，从而阻止其与 mRNA 靶标相互作用。Csr 系统受 BarA/UvrY 型双组分传感器-调节剂系统的控制。除此之外，常见或病原体特异性调节剂控制 Csr 成分的丰度。Csr/Rsm 系统对毒力因子和感染相关生理特性的协调控制有助于病原体在感染的不同阶段适应它们所暴露的快速变化的环境。由于 Csr/Rsm 功能与完全毒力相关，因此它代表了适合抗菌药物开发的目标。
