Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Front Cell Infect Microbiol. 2018 Oct 25;8:378. doi: 10.3389/fcimb.2018.00378. eCollection 2018.
The genus includes three human pathogenic species, , the causative agent of the bubonic and pneumonic plague, and enteric pathogens and that cause a number of gut-associated diseases. Over the past years a large repertoire of RNA-based regulatory systems has been discovered in these pathogens using different RNA-seq based approaches. Among them are several conserved or species-specific RNA-binding proteins, regulatory and sensory RNAs as well as various RNA-degrading enzymes. Many of them were shown to control the expression of important virulence-relevant factors and have a very strong impact on virulence. The precise targets, the molecular mechanism and their role for pathogenicity is only known for a small subset of identified genus- or species-specific RNA-based control elements. However, the ongoing development of new RNA-seq based methods and data analysis methods to investigate the synthesis, composition, translation, decay, and modification of RNAs in the bacterial cell will help us to generate a more comprehensive view of RNA biology in the near future.
该属包括三个人类致病种，即引起鼠疫的鼠疫菌、引起鼠疫的肺鼠疫菌以及引起肠道疾病的肠道病原体 和 。在过去的几年中，使用不同的基于 RNA-seq 的方法，在这些病原体中发现了大量基于 RNA 的调控系统。其中包括几种保守的或种特异性的 RNA 结合蛋白、调节和感应 RNA 以及各种 RNA 降解酶。许多研究表明，它们控制着重要毒力相关因子的表达，并对 毒力有很强的影响。只有一小部分已确定的属特异性或种特异性基于 RNA 的调控元件的精确靶标、分子机制及其对致病性的作用是已知的。然而，新的基于 RNA-seq 的方法和数据分析方法的不断发展，用于研究细菌细胞中 RNA 的合成、组成、翻译、降解和修饰，将有助于我们在不久的将来更全面地了解 RNA 生物学。
