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血浆中野生型巨细胞病毒（CMV）的患者出现更昔洛韦耐药 CMV 视网膜炎。

Ganciclovir-resistant cytomegalovirus (CMV) retinitis in a patient with wild-type CMV in her plasma.

机构信息

Department of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

出版信息

J Clin Microbiol. 2012 May;50(5):1796-9. doi: 10.1128/JCM.00029-12. Epub 2012 Feb 15.

DOI:10.1128/JCM.00029-12
PMID:22337988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3347158/
Abstract

A patient with systemic cytomegalovirus (CMV), including chorioretinitis, received localized and systemic ganciclovir, systemic cidofovir analog, and localized foscarnet. Mutations conferring ganciclovir and cidofovir resistance were detected in CMV from the aqueous fluid but not in CMV from plasma. Quantifying CMV from aqueous fluid was valuable for monitoring the clinical response and predicting resistance.

摘要

一名患有全身巨细胞病毒（CMV）的患者，包括脉络膜视网膜炎，接受了局部和全身更昔洛韦、全身西多福韦类似物和局部膦甲酸治疗。在眼内液中的 CMV 中检测到了赋予更昔洛韦和西多福韦耐药性的突变，但在血浆中的 CMV 中未检测到。定量检测眼内液中的 CMV 对于监测临床反应和预测耐药性非常有价值。

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Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy.抗病毒治疗后观察到的巨细胞病毒 DNA 聚合酶基因突变体的表型多样性。
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Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance.巨细胞病毒 UL97 激酶序列变异体的重组表型分析与更昔洛韦耐药性的关系。
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