髓过氧化物酶阴性皮肤白血病和原始浆细胞样树突状细胞瘤的免疫表型分析。

Immunophenotypic analysis of myeloperoxidase-negative leukemia cutis and blastic plasmacytoid dendritic cell neoplasm.

机构信息

Department of Pathology, Stanford University, Stanford, CA 94305, USA.

出版信息

Am J Clin Pathol. 2012 Mar;137(3):367-76. doi: 10.1309/AJCP9IS9KFSVWKGH.

Abstract

Myeloid leukemia cutis (LC) and blastic plasmacytoid dendritic cell neoplasm (BPDCN) are morphologically indistinguishable malignancies that frequently manifest in the skin. Separating myeloperoxidase-negative LC from BPDCN may be particularly challenging. We identified a panel of immunohistochemical stains to distinguish myeloid LC (23 cases) from BPDCN (12 cases): myeloperoxidase, which stained 7 cases (30%) of LC and 0 cases (0%) of BPDCN; CD56, which stained 12 cases (52%) of LC and all 12 cases (100%) of BPDCN; CD4, which stained 2 cases (9%) of LC and all 12 cases (100%) of BPDCN; CD123, which stained 4 cases (17%) of LC and 10 cases (83%) of BPDCN; and Tcl-1, which stained 2 cases (9%) of LC and 9 (82%) of 11 cases of BPDCN. It is interesting that CD33 was not helpful; it stained 18 (78%) cases of LC and 11 cases (92%) of BPDCN. Our results indicate that a panel that includes CD4, CD56, CD123, and Tcl-1 can appropriately distinguish between these 2 entities.

摘要

骨髓性皮肤白血病 (LC) 和原始细胞性浆细胞样树突状细胞瘤 (BPDCN) 是形态上无法区分的恶性肿瘤，常发生于皮肤。从骨髓性过氧化物酶阴性的 LC 中区分 BPDCN 可能特别具有挑战性。我们确定了一组免疫组织化学染色来区分髓性 LC（23 例）和 BPDCN（12 例）：髓过氧化物酶，其染色了 7 例（30%）的 LC 和 0 例（0%）的 BPDCN；CD56，其染色了 12 例（52%）的 LC 和所有 12 例（100%）的 BPDCN；CD4，其染色了 2 例（9%）的 LC 和所有 12 例（100%）的 BPDCN；CD123，其染色了 4 例（17%）的 LC 和 10 例（83%）的 BPDCN；和 Tcl-1，其染色了 2 例（9%）的 LC 和 9 例（82%）的 11 例 BPDCN。有趣的是，CD33 没有帮助；它染色了 18 例（78%）的 LC 和 11 例（92%）的 BPDCN。我们的结果表明，包含 CD4、CD56、CD123 和 Tcl-1 的一组可以适当区分这两种实体。