Department of Pathology, Stanford University, Stanford, CA 94305, USA.
Am J Clin Pathol. 2012 Mar;137(3):367-76. doi: 10.1309/AJCP9IS9KFSVWKGH.
Myeloid leukemia cutis (LC) and blastic plasmacytoid dendritic cell neoplasm (BPDCN) are morphologically indistinguishable malignancies that frequently manifest in the skin. Separating myeloperoxidase-negative LC from BPDCN may be particularly challenging. We identified a panel of immunohistochemical stains to distinguish myeloid LC (23 cases) from BPDCN (12 cases): myeloperoxidase, which stained 7 cases (30%) of LC and 0 cases (0%) of BPDCN; CD56, which stained 12 cases (52%) of LC and all 12 cases (100%) of BPDCN; CD4, which stained 2 cases (9%) of LC and all 12 cases (100%) of BPDCN; CD123, which stained 4 cases (17%) of LC and 10 cases (83%) of BPDCN; and Tcl-1, which stained 2 cases (9%) of LC and 9 (82%) of 11 cases of BPDCN. It is interesting that CD33 was not helpful; it stained 18 (78%) cases of LC and 11 cases (92%) of BPDCN. Our results indicate that a panel that includes CD4, CD56, CD123, and Tcl-1 can appropriately distinguish between these 2 entities.
骨髓性皮肤白血病 (LC) 和原始细胞性浆细胞样树突状细胞瘤 (BPDCN) 是形态上无法区分的恶性肿瘤，常发生于皮肤。从骨髓性过氧化物酶阴性的 LC 中区分 BPDCN 可能特别具有挑战性。我们确定了一组免疫组织化学染色来区分髓性 LC（23 例）和 BPDCN（12 例）：髓过氧化物酶，其染色了 7 例（30%）的 LC 和 0 例（0%）的 BPDCN；CD56，其染色了 12 例（52%）的 LC 和所有 12 例（100%）的 BPDCN；CD4，其染色了 2 例（9%）的 LC 和所有 12 例（100%）的 BPDCN；CD123，其染色了 4 例（17%）的 LC 和 10 例（83%）的 BPDCN；和 Tcl-1，其染色了 2 例（9%）的 LC 和 9 例（82%）的 11 例 BPDCN。有趣的是，CD33 没有帮助；它染色了 18 例（78%）的 LC 和 11 例（92%）的 BPDCN。我们的结果表明，包含 CD4、CD56、CD123 和 Tcl-1 的一组可以适当区分这两种实体。
