Sherjil Ahmad, us Saeed Zaheer, Shehzad Sohail, Amjad Rabia
Department of Paediatrics, HIT Hospital, Taxila, Cantt, Pakistan.
J Ayub Med Coll Abbottabad. 2010 Jul-Sep;22(3):71-3.
Iron deficiency anaemia and febrile seizures are two common diseases in children worldwide as well as in our country. Iron insufficiency is known to cause neurological symptoms like behavioural changes, poor attention span and learning deficits in children. Therefore, it may also be associated with other neurological disturbances like febrile seizures in children. Objective of our case-control study was to find association between iron deficiency anaemia and febrile seizures in children.
This multicentre study was conducted in Department of Paediatrics HIT Hospital Taxila Cantt, Department of Paediatrics CMH Mangla and Department of Paediatrics POF Hospital Wah Cantt, from June 2008 to June 2010. Three hundred and ten children aged between 6 months to 6 years were included in the study. One hundred and fifty-seven children who presented with febrile seizures were our cases, while, 153 children who presented with febrile illnesses without seizures were recruited as controls. All patients were assessed for iron deficiency anaemia by measuring haemoglobin level, serum ferritin level, Mean Corpuscular Haemoglobin Concentration (MCHC) and Mean Corpuscular Volume (MCV). Patients with iron deficiency anaemia amongst controls and cases were documented. Percentages and Odds ratio were derived from the collected data.
31.85% of cases (50 out of 157) had iron deficiency anaemia whereas, 19.6% of controls (30 out of 153) were found to have iron deficiency anaemia as revealed by low levels of haemoglobin level, serum ferritin level. Mean Corpuscular Haemoglobin Concentration and Mean Corpuscular Volume. Odds ratio was 1.93.
Patients with febrile seizures are 1.93 times more likely to have iron deficiency anaemia compared to febrile patients without seizures.
缺铁性贫血和热性惊厥是全球以及我国儿童中的两种常见疾病。已知铁缺乏会导致儿童出现行为改变、注意力不集中和学习障碍等神经症状。因此，它也可能与儿童热性惊厥等其他神经紊乱有关。我们这项病例对照研究的目的是找出儿童缺铁性贫血与热性惊厥之间的关联。
这项多中心研究于2008年6月至2010年6月在塔克西拉中央医院儿科、芒格拉综合军事医院儿科和瓦赫中央监狱医院儿科进行。研究纳入了310名年龄在6个月至6岁之间的儿童。157名出现热性惊厥的儿童为病例组，153名出现无惊厥热性疾病的儿童被招募为对照组。通过测量血红蛋白水平、血清铁蛋白水平、平均红细胞血红蛋白浓度（MCHC）和平均红细胞体积（MCV）对所有患者进行缺铁性贫血评估。记录对照组和病例组中缺铁性贫血的患者。从收集的数据中得出百分比和比值比。
病例组中有31.85%（157例中的50例）患有缺铁性贫血，而对照组中有19.6%（153例中的30例）被发现患有缺铁性贫血，这通过血红蛋白水平、血清铁蛋白水平、平均红细胞血红蛋白浓度和平均红细胞体积水平较低得以体现。比值比为1.93。
与无惊厥的热性疾病患者相比，热性惊厥患者患缺铁性贫血的可能性高1.93倍。
