Fallah R, Tirandazi B, Akhavan Karbasi S, Golestan M
Pediatric Neurologist, Associate Professor ,Department of Pediatrics, Growth Disorders of Children Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
General Physician, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Iran J Ped Hematol Oncol. 2013;3(1):200-3. Epub 2013 Jan 22.
Febrile seizure (FS) is the most common childhood seizures which occur in 2-5% of children. Studies about association between iron deficiency and febrile seizure have shown contradictory results. The purpose of this study was to compare the iron status of children with first febrile seizure and healthy control group.
In an analytic case-control study , iron status of 6 to 60 months old admitted children with first FS to Shahid Sadoughi Hospital from December 2011 to August 2012 was evaluated and compared with healthy age and sex matched control children whom were referred for routine health care to primary health care center of Azadshar Yazd, Iran.
Forty five (44%) girls and 55 boys with a mean age of 23.7 ± 14.3 months were evaluated. In children with FS , hemoglobin level (11.46 ± 1.18 g/dl vs. 11.9 ± 0.89 g/dl, p= 0.042) , serum iron levels (48.91 ± 22.96 μg/dl vs. 75.13 ± 35.57 μg/dl , p= 0.001) and serum ferritin level (38.52 ± 11.38 ng/ml vs. 54.32 ± 13.46 ng/ml, p= 0.001) were lower than in healthy children group . Iron deficiency (48% vs. 28% , odds ratio 4.3, p=0.03) and iron deficiency anemia (22% vs. 10% , odds ratio = 3.16, p= 0.04) were more frequent in children with FS.
Based on the result of this study, iron deficiency could be an important risk factor for development of febrile convulsion. Evaluation of iron status is encouraged to be performed in children with febrile seizure.
热性惊厥（FS）是最常见的儿童惊厥，在2%至5%的儿童中发生。关于缺铁与热性惊厥之间关联的研究结果相互矛盾。本研究的目的是比较首次发生热性惊厥的儿童与健康对照组儿童的铁状态。
在一项分析性病例对照研究中，对2011年12月至2012年8月入住沙希德·萨多吉医院的6至60个月大首次发生FS的儿童的铁状态进行评估，并与年龄和性别匹配的健康对照儿童进行比较，这些健康对照儿童因常规医疗保健被转诊至伊朗亚兹德阿扎德沙尔的初级卫生保健中心。
评估了45名（44%）女孩和55名男孩，平均年龄为23.7±14.3个月。FS儿童的血红蛋白水平（11.46±1.18 g/dl对11.9±0.89 g/dl，p = 0.042）、血清铁水平（48.91±22.96 μg/dl对75.13±35.57 μg/dl，p = 0.001）和血清铁蛋白水平（38.52±11.38 ng/ml对54.32±13.46 ng/ml，p = 0.001）低于健康儿童组。FS儿童缺铁（48%对28%，优势比4.3，p = 0.03）和缺铁性贫血（22%对10%，优势比 = 3.16，p = 0.04）更为常见。
基于本研究结果，缺铁可能是热性惊厥发生的重要危险因素。鼓励对热性惊厥儿童进行铁状态评估。
