韩国前瞻性病例对照研究缺铁与儿童热性惊厥风险。
Prospective case control study of iron deficiency and the risk of febrile seizures in children in South Korea.
机构信息
Department of Pediatrics, School of Medicine, Kyung Hee University, 23, Kyung Hee Dae-ro, Dongdaemun-gu, Seoul, 130-872, South Korea.
出版信息
BMC Pediatr. 2019 Sep 4;19(1):309. doi: 10.1186/s12887-019-1675-4.
BACKGROUND
Febrile seizures are the most common type of seizure in the first 5 years of life, and many factors that increase seizure risk have been identified. This study was performed to examine the association between iron status and febrile seizures in children in South Korea.
METHODS
A prospective unmatched case control study was performed in 63 cases of febrile seizures and 65 controls with febrile illness but no seizures.
RESULTS
Serum iron, plasma ferritin, and transferrin saturation were significantly lower in children with febrile seizures compared to the controls. Iron deficiency, defined as ferritin < 30 ng/mL, was more prevalent in the febrile seizure group (49.2%) than in the control group (16.9%). Serum iron < 22 ng/dL (odds ratio 3.42, 95% confidence interval [CI] 1.31-8.9, P = 0.012) and ferritin < 30 ng/mL (odds ratio 6.18, 95% CI 2.32-16.42, P < 0.001) were associated with increased risk of developing febrile seizures in multivariate logistic regression analysis.
CONCLUSION
These observations suggest that iron deficiency prior to development of anemia may increase risk of febrile seizures.
背景
热性惊厥是生命前 5 年最常见的惊厥类型，许多增加惊厥风险的因素已被确定。本研究旨在探讨韩国儿童铁状态与热性惊厥之间的关系。
方法
对 63 例热性惊厥患儿和 65 例发热但无惊厥的对照患儿进行前瞻性非匹配病例对照研究。
结果
与对照组相比，热性惊厥患儿的血清铁、血浆铁蛋白和转铁蛋白饱和度显著降低。铁缺乏症（定义为铁蛋白 < 30ng/mL）在热性惊厥组（49.2%）比对照组（16.9%）更为常见。血清铁 < 22ng/dL（比值比 3.42，95%置信区间 [CI] 1.31-8.9，P = 0.012）和铁蛋白 < 30ng/mL（比值比 6.18，95% CI 2.32-16.42，P < 0.001）与多变量逻辑回归分析中热性惊厥发生风险增加相关。
结论
这些观察结果表明，在发生贫血之前的铁缺乏可能会增加热性惊厥的风险。
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