儿童缺铁与热性惊厥之间的关联。
The association between iron deficiency and febrile seizures in childhood.
作者信息
Hartfield Dawn S, Tan Jonathan, Yager Jerome Y, Rosychuk Rhonda J, Spady Don, Haines Christina, Craig William R
机构信息
Department of Pediatrics, University of Alberta, Edmonton, Canada.
出版信息
Clin Pediatr (Phila). 2009 May;48(4):420-6. doi: 10.1177/0009922809331800. Epub 2009 Feb 19.
PURPOSE
The purpose of this study was to determine the association between iron deficiency and febrile seizures in a large cohort of children aged 6 to 36 months.
METHODS
A retrospective case control study with 361 patients who presented with febrile seizures to the emergency department and 390 otherwise healthy controls who presented with a febrile illness to the emergency department were reviewed to determine iron status using the MCV, RDW, and hemoglobin.
RESULTS
A total of 9% of cases had iron deficiency (ID) and 6% had iron deficiency anemia (IDA), compared to 5% and 4% of controls respectively. The conditional logistic regression odds ratio for ID in patients with febrile seizures was 1.84 (95% CI, 1.02-3.31).
CONCLUSION
Children with febrile seizures were almost twice as likely to be iron deficient as those with febrile illness alone. The results suggest that screening for ID should be considered in children presenting with febrile seizure.
目的
本研究旨在确定6至36个月大的一大群儿童中缺铁与热性惊厥之间的关联。
方法
进行一项回顾性病例对照研究，对361例因热性惊厥到急诊科就诊的患者和390例因发热性疾病到急诊科就诊的健康对照者进行审查，使用平均红细胞体积（MCV）、红细胞分布宽度（RDW）和血红蛋白来确定铁状态。
结果
病例组中共有9%的患者缺铁（ID），6%的患者缺铁性贫血（IDA），对照组中这一比例分别为5%和4%。热性惊厥患者缺铁的条件逻辑回归比值比为1.84（95%可信区间，1.02 - 3.31）。
结论
热性惊厥患儿缺铁的可能性几乎是单纯发热性疾病患儿的两倍。结果表明，对于出现热性惊厥的儿童应考虑进行缺铁筛查。
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