Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Seizure. 2012 Oct;21(8):603-5. doi: 10.1016/j.seizure.2012.06.010. Epub 2012 Jul 15.
The aim of this study was to determine the association between iron status and febrile seizures in children aged 6 months to 5 years.
This prospective case-control study enrolled 300 children who presented with febrile seizures (case group) and 200 children who presented with a febrile illness without seizures (control group) from March 2007 to January 2009. Hemoglobin, mean corpuscular volume and serum ferritin concentration were compared in the two groups in relation to age, sex and use of iron supplementation.
Patients with febrile seizures were more frequently iron deficient as defined by a serum ferritin level below 20 ng/dl (56.6% vs. 24.8%, P=0.0001). Mean hemoglobin concentration was 10.8 g/dl in the control group and 11.7 g/dl in the case group (P<0.05). The difference between groups in mean corpuscular volume was not statistically significant (75.5 fl vs. 74.4 fl, P<0.130).
Low serum ferritin concentration and low iron status may be risk factors for the development of febrile seizures.
本研究旨在确定铁状态与 6 个月至 5 岁儿童热性惊厥之间的关系。
本前瞻性病例对照研究纳入了 2007 年 3 月至 2009 年 1 月期间因热性惊厥（病例组）和无热性惊厥发热性疾病（对照组）就诊的 300 名儿童和 200 名儿童。比较两组在年龄、性别和铁补充剂使用方面的血红蛋白、平均红细胞体积和血清铁蛋白浓度。
根据血清铁蛋白水平<20ng/dl 定义，热性惊厥患者更常缺铁（56.6% vs. 24.8%，P=0.0001）。对照组的平均血红蛋白浓度为 10.8g/dl，病例组为 11.7g/dl（P<0.05）。两组平均红细胞体积之间的差异无统计学意义（75.5fl vs. 74.4fl，P<0.130）。
低血清铁蛋白浓度和低铁状态可能是热性惊厥发生的危险因素。
