Ashby J, Tinwell H, Callander R D
ICI Central Toxicology Laboratory, Macclesfield, Ches., Great Britain.
Mutat Res. 1990 Nov;245(3):227-30. doi: 10.1016/0165-7992(90)90055-o.
Urethane is shown to be active in the mouse bone-marrow micronucleus assay when administered as a single dose by either gavage or intraperitoneal injection. The magnitude of the response using the two routes was not statistically significantly different. N,N-Dimethylurethane (DMU) is shown to be mutagenic to Salmonella and active in the bone-marrow micronucleus assay by both routes of administration. The activity of DMU in the bone marrow precludes elimination of ethanol, yielding cyanate ion, as an explanation for the micronucleus-inducing activity of urethane.
当通过灌胃或腹腔注射单次给药时，氨基甲酸乙酯在小鼠骨髓微核试验中显示出活性。使用这两种途径的反应强度在统计学上没有显著差异。N,N-二甲基氨基甲酸乙酯（DMU）对沙门氏菌具有致突变性，并且通过两种给药途径在骨髓微核试验中均有活性。DMU在骨髓中的活性排除了乙醇代谢产生氰酸根离子作为氨基甲酸乙酯诱导微核活性的解释。
