Liegibel U, Tinwell H, Callander R D, Schmezer P, Ashby J
ICI Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
Mutagenesis. 1992 Nov;7(6):471-4. doi: 10.1093/mutage/7.6.471.
The methylating agent streptozotocin is active in the mouse bone marrow micronucleus assay following a single intraperitoneal injection of 150-180 mg/kg. This correlates with its previously reported toxicity to mouse germ cells when administered by the same route of exposure. The potent mutagenicity of streptozotocin to strain G46 of Salmonella typhimurium is compared with its much weaker activity in strain TA1535. The genotoxicity of streptozotocin in vivo is reviewed.
甲基化剂链脲佐菌素在腹腔注射150 - 180毫克/千克后，在小鼠骨髓微核试验中具有活性。这与其通过相同暴露途径给药时先前报道的对小鼠生殖细胞的毒性相关。将链脲佐菌素对鼠伤寒沙门氏菌G46菌株的强致突变性与其在TA1535菌株中弱得多的活性进行比较。综述了链脲佐菌素在体内的遗传毒性。
