Institute for Vascular Signalling, Centre for Molecular Medicine, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, D-60596 Frankfurt am Main, Germany.
Curr Vasc Pharmacol. 2012 Sep;10(5):532-8. doi: 10.2174/157016112801784639.
Diabetes mellitus is associated with the accelerated development of vascular disease and there is evidence that platelets actively contribute to this process. Certainly, platelets are able to modulate the function of endothelial and vascular smooth muscle cells via the direct release of growth factors and pro-inflammatory chemokines but also via the production of microparticles which function as a transcellular delivery system for micro RNAs. This article reviews the intracellular signaling mechanisms underlying the increased activation of diabetic platelets and the involvement of platelets in atherothrombosis development.
糖尿病与血管疾病的加速发展有关，有证据表明血小板在此过程中起积极作用。当然，血小板能够通过直接释放生长因子和促炎趋化因子，以及通过产生作为 microRNAs 细胞间传递系统的微粒体，来调节内皮细胞和血管平滑肌细胞的功能。本文综述了糖尿病血小板过度激活的细胞内信号转导机制以及血小板在动脉血栓形成发展中的作用。
