Cortez-Espinosa Nancy, Mayoral Laura Perez-Campos, Perez-Campos Eduardo, Cabrera Fuentes Hector Alejandro, Mayoral Eduardo Perez-Campos, Martínez-Cruz Ruth, Canseco Socorro Pina, Andrade Gabriel Mayoral, Cruz Margarito Martinez, Velasco Itandehui Gallegos, Cruz Pedro Hernandez
Centro de Investigación Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
Department of Investigation Medicine-UNAM-UABJO, Faculty of School of Medicine, UABJO University, CP 60120, Oaxaca, Mexico.
Curr Vasc Pharmacol. 2017;15(3):207-217. doi: 10.2174/1570161115666170126130309.
The association between type 2 diabetes mellitus (T2DM) and systemic inflammation may increase platelet reactivity and the accelerated development of vascular disease. Platelets are able to modulate the function of immune cells via the direct release of growth factors and pro-inflammatory chemokines through the production of microvesicles. The microvesicles trigger a transcellular delivery system of bioactive molecules to other cells acting as vectors in the exchange of biological information. Here, we consider the influence of platelets and platelet-derived microvesicles on cells of the immune system and the implications in the pathogenesis of T2DM.
2型糖尿病（T2DM）与全身炎症之间的关联可能会增加血小板反应性以及血管疾病的加速发展。血小板能够通过微囊泡的产生直接释放生长因子和促炎趋化因子来调节免疫细胞的功能。微囊泡触发了生物活性分子向其他细胞的跨细胞递送系统，在生物信息交换中充当载体。在此，我们探讨血小板及血小板衍生微囊泡对免疫系统细胞的影响以及在T2DM发病机制中的意义。
