患有出血性或感染性休克的重症外科患者的BK病毒血症
BK viremia in critically ill surgical patients with hemorrhagic or septic shock.
作者信息
Nass Maximilian, Weissbrich Benedikt, Huber Moritz, Schneider Elisabeth Marion, Weiss Manfred
机构信息
Department of Anaesthesiology, University Hospital Ulm, Steinhoevelstr, 9, 89075 Ulm, Germany.
出版信息
BMC Res Notes. 2012 Feb 16;5:100. doi: 10.1186/1756-0500-5-100.
BACKGROUND
Infections with polyomavirus BK virus (BKV) are a common cause of renal dysfunction after renal transplantation and may also be harmful in surgical patients with shock. The aim of the present study was to determine the frequency of BKV viremia in critically ill surgical patients with septic or hemorrhagic shock, and, if viremia is detectable, whether viremia may be associated with renal dysfunction.
FINDINGS
A total of 125 plasma samples from 44 critically ill surgical patients with septic or hemorrhagic shock were tested by real-time polymerase chain reaction (PCR) for BKV DNA during their stay on the intensive care unit (ICU). BKV viremia occurred in four patients, i.e. in three of the septic and in one of the hemorrhagic shock group. There was no association between viremia and renal dysfunction. All positive samples contained a low viral load (< 500 copies/ml).
CONCLUSIONS
Since BK viremia was rarely found and with low viral load only in critically ill surgical patients with shock, it is very unlikely that BK viremia results in BK nephropathy later on.
背景
多瘤病毒BK病毒（BKV）感染是肾移植后肾功能不全的常见原因，对休克手术患者也可能有害。本研究的目的是确定脓毒症或失血性休克的重症手术患者中BKV病毒血症的发生率，以及如果可检测到病毒血症，病毒血症是否可能与肾功能不全相关。
研究结果
对44例脓毒症或失血性休克的重症手术患者在重症监护病房（ICU）期间的125份血浆样本进行实时聚合酶链反应（PCR）检测BKV DNA。4例患者出现BKV病毒血症，即脓毒症组3例，失血性休克组1例。病毒血症与肾功能不全之间无关联。所有阳性样本的病毒载量均较低（<500拷贝/ml）。
结论
由于仅在休克的重症手术患者中很少发现BK病毒血症且病毒载量较低，BK病毒血症导致后期BK肾病的可能性极小。
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