肥胖及其相关疾病：微生物组的作用？
Obesity and its associated disease: a role for microbiota?
机构信息
Division of Digestive Diseases, Emory University, Atlanta, GA, USA.
出版信息
Neurogastroenterol Motil. 2012 Apr;24(4):305-11. doi: 10.1111/j.1365-2982.2012.01895.x. Epub 2012 Feb 20.
Abstract
BACKGROUND
Gut microbiota have recently been implicated in the pathogenesis of the obesity and its related metabolic diseases. A variety of factors including diet, genetic background, environment and host innate and adaptive immune responses define an individual's gut microbiota.
PURPOSE
In this review we outline potential mechanisms by which gut microbiota can contribute to the development of obesity focusing on specific processes such as microbial energy extraction, microbiota induced-inflammation and regulation of appetite. We review the current understanding of each of these processes on regulating metabolism and examine potential therapeutic strategies for the treatment or prevention of the metabolic syndrome. We explore the hypothesis that alteration in gut microbiota may be an initial event leading to altered feeding behavior and/or systemic inflammation, ultimately leading to weight gain and the metabolic syndrome.
摘要
背景
肠道微生物群最近被牵涉到肥胖及其相关代谢疾病的发病机制中。饮食、遗传背景、环境和宿主固有及适应性免疫反应等多种因素决定了个体的肠道微生物群。
目的
在本综述中，我们概述了肠道微生物群如何通过特定的过程（如微生物能量提取、微生物诱导的炎症和食欲调节）来促进肥胖的发展。我们回顾了这些过程中每一个对代谢调节的理解，并研究了治疗或预防代谢综合征的潜在治疗策略。我们探讨了这样一种假说，即肠道微生物群的改变可能是导致进食行为和/或全身炎症改变的初始事件，最终导致体重增加和代谢综合征。
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