Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Chin Med J (Engl). 2011 Nov;124(22):3816-9.
To review the vasorelaxant effects of hydrogen sulfide (H(2)S) in arterial rings in the cardiovascular system under both physiological and pathophysiological conditions and the possible mechanisms involved.
The data in this review were obtained from Medline and Pubmed sources from 1997 to 2011 using the search terms "hydrogen sulfide" and "vascular relaxation".
Articles describing the role of hydrogen sulfide in the regulation of vascular activity and its vasorelaxant effects were selected.
H(2)S plays an important role in the regulation of cardiovascular tone. The vasomodulatory effects of H(2)S depend on factors including concentration, species and tissue type. The H(2)S donor, sodium hydrosulfide (NaHS), causes vasorelaxation of rat isolated aortic rings in a dose-dependent manner. This effect was more pronounced than that observed in pulmonary arterial rings. The expression of K(ATP) channel proteins and mRNA in the aortic rings was increased compared with pulmonary artery rings. H(2)S is involved in the pathogenesis of a variety of cardiovascular diseases. Downregulation of the endogenous H(2)S pathway is an important factor in the pathogenesis of cardiovascular diseases. The vasorelaxant effects of H(2)S have been shown to be mediated by activation of K(ATP) channels in vascular smooth muscle cells and via the induction of acidification due to activation of the Cl(-)/HCO(3)(-) exchanger. It is speculated that the mechanisms underlying the vasoconstrictive function of H(2)S in the aortic rings involves decreased NO production and inhibition of cAMP accumulation.
H(2)S is an important endogenous gasotransmitter in the cardiovascular system and acts as a modulator of vascular tone in the homeostatic regulation of blood pressure.
综述在生理和病理生理条件下，心血管系统中硫化氢（H2S）对动脉环的血管舒张作用及其可能的作用机制。
本综述中的数据来自 1997 年至 2011 年 Medline 和 Pubmed 资源，使用的检索词为“硫化氢”和“血管舒张”。
选择了描述 H2S 在调节血管活性及其血管舒张作用中的作用的文章。
H2S 在心血管张力调节中起重要作用。H2S 的血管调节作用取决于浓度、物种和组织类型等因素。H2S 供体硫氢化钠（NaHS）以剂量依赖性方式引起大鼠离体主动脉环的血管舒张。这种作用比在肺动脉环中观察到的更为明显。与肺动脉环相比，主动脉环中 KATP 通道蛋白和 mRNA 的表达增加。H2S 参与多种心血管疾病的发病机制。内源性 H2S 途径的下调是心血管疾病发病机制中的一个重要因素。H2S 的血管舒张作用被证明是通过血管平滑肌细胞中 KATP 通道的激活以及由于 Cl(-)/HCO3(-)交换体的激活导致酸化的诱导来介导的。据推测，H2S 在主动脉环中的血管收缩功能的机制涉及 NO 生成减少和 cAMP 积累抑制。
H2S 是心血管系统中的一种重要内源性气体递质，作为血压稳态调节中血管张力的调节剂。
