Sun Hai-Jian, Wu Zhi-Yuan, Nie Xiao-Wei, Wang Xin-Yu, Bian Jin-Song
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Department of Endocrinology, The First Affiliated Hospital of Shenzhen University (Shenzhen Second People's Hospital), Shenzhen, China.
Front Pharmacol. 2021 Oct 26;12:651884. doi: 10.3389/fphar.2021.651884. eCollection 2021.
Cardiovascular diseases are the most common complications of diabetes, and diabetic cardiomyopathy is a major cause of people death in diabetes. Molecular, transcriptional, animal, and clinical studies have discovered numerous therapeutic targets or drugs for diabetic cardiomyopathy. Within this, hydrogen sulfide (HS), an endogenous gasotransmitter alongside with nitric oxide (NO) and carbon monoxide (CO), is found to play a critical role in diabetic cardiomyopathy. Recently, the protective roles of HS in diabetic cardiomyopathy have attracted enormous attention. In addition, HS donors confer favorable effects in myocardial infarction, ischaemia-reperfusion injury, and heart failure under diabetic conditions. Further studies have disclosed that multiplex molecular mechanisms are responsible for the protective effects of HS against diabetes-elicited cardiac injury, such as anti-oxidative, anti-apoptotic, anti-inflammatory, and anti-necrotic properties. In this review, we will summarize the current findings on HS biology and pharmacology, especially focusing on the novel mechanisms of HS-based protection against diabetic cardiomyopathy. Also, the potential roles of HS in diabetes-aggravated ischaemia-reperfusion injury are discussed.
心血管疾病是糖尿病最常见的并发症，而糖尿病性心肌病是糖尿病患者死亡的主要原因。分子、转录、动物和临床研究已经发现了许多针对糖尿病性心肌病的治疗靶点或药物。其中，硫化氢（HS）作为一种与一氧化氮（NO）和一氧化碳（CO）并列的内源性气体信号分子，被发现在糖尿病性心肌病中起关键作用。最近，HS在糖尿病性心肌病中的保护作用引起了极大关注。此外，HS供体在糖尿病条件下对心肌梗死、缺血再灌注损伤和心力衰竭具有有益作用。进一步的研究表明，多种分子机制介导了HS对糖尿病所致心脏损伤的保护作用，如抗氧化、抗凋亡、抗炎和抗坏死特性。在本综述中，我们将总结HS生物学和药理学的当前研究结果，特别关注基于HS保护糖尿病性心肌病的新机制。此外，还讨论了HS在糖尿病加重的缺血再灌注损伤中的潜在作用。
