Laboratory of Viral Infection, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
FEBS J. 2012 Apr;279(8):1399-406. doi: 10.1111/j.1742-4658.2012.08534.x. Epub 2012 Mar 23.
The endosomal sorting complexes required for transport (ESCRTs) mediate membrane fission from the cytoplasmic face of the bud neck. ESCRTs were originally identified as factors involved in multivesicular body vesicle biogenesis in yeast but have since been shown to function in other membrane fission events in mammalian cells, including enveloped virus budding and the abscission step of cytokinesis. Several recent studies have revealed that not all ESCRT factors are required for each of these biological processes, and this review summarizes our current understanding of the different requirements for ESCRT factors in these three different ESCRT-mediated mammalian membrane fission processes.
内体分选复合物需要运输（ESCRTs）介导从芽颈细胞质面的膜裂变。ESCRTs 最初被确定为参与酵母多泡体小泡生物发生的因子，但此后已证明它们在哺乳动物细胞中的其他膜裂变事件中起作用，包括包膜病毒出芽和胞质分裂的分离步骤。最近的几项研究表明，并非所有 ESCRT 因子都需要这些生物过程中的每一个，本综述总结了我们目前对这些三种不同的 ESCRT 介导的哺乳动物膜裂变过程中 ESCRT 因子的不同要求的理解。
