Medicine Service and Center for Surgical Medical Acute care Research and Transitions (C-SMART), Birmingham VA Medical Center, Birmingham, AL, USA.
J Arthroplasty. 2012 Sep;27(8):1507-12. doi: 10.1016/j.arth.2011.12.010. Epub 2012 Feb 15.
We assessed important patient risk factors for postoperative periprosthetic fractures after revision total hip arthroplasty (THA) using prospectively collected Institutional Joint Registry data. We used univariate and multivariable-adjusted Cox regression analyses. There were 330 postoperative periprosthetic fractures after 6281 revision THAs. In multivariable-adjusted analyses, hazard ratio (95% confidence interval) of periprosthetic fracture was higher for women (1.66 [1.32-2.080], P < .001), a higher Deyo-Charlson comorbidity index of 2 (1.46 [1.03-2.07]) and index of 3+ (2.01 [1.48-2.73]; overall, P < .001), and operative diagnosis, especially previous nonunion (5.76 [2.55-13.02]; overall, P < .001). Hazard ratio was lower in patients 61 to 70 years old (0.64 [0.49-0.84]) and 71 to 80 years old (0.57 [0.43-0.76]) compared with those younger than 60 years (overall, P < .0001). Our study identified important modifiable and unmodifiable risk factors for fractures after revision THA.
我们使用前瞻性收集的机构关节登记数据评估了全髋关节翻修术后假体周围骨折的重要患者风险因素。我们使用了单变量和多变量调整的 Cox 回归分析。在 6281 例全髋关节翻修术后,有 330 例出现术后假体周围骨折。在多变量调整分析中,女性发生假体周围骨折的风险比(95%置信区间)更高(1.66 [1.32-2.080],P<.001),Deyo-Charlson 合并症指数为 2(1.46 [1.03-2.07])和指数为 3+(2.01 [1.48-2.73];总体,P<.001)更高,以及手术诊断,特别是先前的骨不连(5.76 [2.55-13.02];总体,P<.001)。与 60 岁以下的患者相比,61-70 岁(0.64 [0.49-0.84])和 71-80 岁(0.57 [0.43-0.76])的患者风险比降低(总体,P<.0001)。我们的研究确定了全髋关节翻修术后骨折的重要可改变和不可改变的风险因素。