University of Utrecht, Faculty of Medicine, Utrecht, The Netherlands.
J Cyst Fibros. 2012 Jul;11(4):340-3. doi: 10.1016/j.jcf.2012.01.006. Epub 2012 Feb 18.
Mycobacterium abscessus is a nontuberculous mycobacterium that is increasingly recognized as an opportunistic pathogen in cystic fibrosis (CF) patients. Factors that predispose CF patients to infection by this environmental bacterium remain unknown. In a case-control study of 22 CF patients with M. abscessus infection and 22 CF controls, we investigated risk factors for MAB infection as well as the positioning of MAB infection in relation to the other pathogens infecting CF patients. No clear risk factors were found; steroid treatment and CF related diabetes were equally common among cases and controls. M. abscessus disease affects CF patients of varying age, lung function and co-morbidities. Antimicrobial maintenance therapy did not prevent M. abscessus infection. A history of Stenotrophomonas maltophilia infection was significantly more frequent among cases than among controls and there may be a relation with Aspergillus fumigatus infection, or both may be signs of advanced lung damage that predisposes to MAB disease. The absence of clear risk factors and the omnipresence of MAB in the environment suggest that MAB infection in CF patients is a random event. Its symptoms and impact on lung function seem to warrant treatment.
脓肿分枝杆菌是一种非结核分枝杆菌，它作为一种机会性病原体，在囊性纤维化（CF）患者中越来越受到关注。但导致 CF 患者易受这种环境细菌感染的因素仍不清楚。在一项对 22 名患有脓肿分枝杆菌感染的 CF 患者和 22 名 CF 对照者的病例对照研究中，我们调查了 MAB 感染的危险因素，以及 MAB 感染在 CF 患者感染的其他病原体中的定位。未发现明确的危险因素；皮质类固醇治疗和 CF 相关糖尿病在病例和对照组中同样常见。脓肿分枝杆菌病影响 CF 患者的年龄、肺功能和合并症各异。抗菌维持治疗并不能预防脓肿分枝杆菌感染。与对照组相比，病例组中史氏假单胞菌感染的病史明显更为频繁，这可能与烟曲霉感染有关，或者两者都可能是导致 MAB 疾病的晚期肺损伤的迹象。由于不存在明确的危险因素，而且环境中普遍存在 MAB，因此 CF 患者的 MAB 感染似乎是一种随机事件。其症状和对肺功能的影响似乎需要治疗。
