Programme National de Nutrition, Kinshasa, DRC, Democratic Republic of Congo.
Food Chem Toxicol. 2012 May;50(5):1517-23. doi: 10.1016/j.fct.2012.02.001. Epub 2012 Feb 10.
Fifty konzo cases were identified in four villages in Popokabaka Health Zone, DRC. One third of people had only one meal per day, mainly of cassava flour consumed as a thick porridge (fufu) and pounded, boiled cassava leaves. Retention of cyanogens in flour resulted from short soaking of cassava roots. A 1.5 years intervention was made in the largest village Kay Kalenge, where the wetting method was taught to all women of the village, who accepted it willingly. The total cyanide content of cassava flour was reduced to below 10 ppm. Fufu from treated flour tasted and stored better than fufu from untreated flour. The mean urinary thiocyanate content of 100 school children reduced from 332 to 130 μmole/L and the number of samples exceeding 350 μmole/L decreased from 26 to 0 during the intervention. No new konzo cases occurred, which included two dry seasons when konzo peaks. Konzo was first identified by Dr. Trolli in 1938 in Popokabaka Health Zone and it has now been prevented for the first time in the same area. The methodology is now in use in Boko Health Zone and we believe it is the most effective way to control konzo in tropical Africa.
在刚果民主共和国波波卡巴卡卫生区的四个村庄中发现了 50 例科佐病。三分之一的人每天只吃一顿饭，主要是用木薯粉做的稠粥（福福）和捣碎的、煮熟的木薯叶。木薯根浸泡时间短导致氰化物在面粉中保留。在最大的村庄卡延莱格（Kay Kalenge）进行了为期 1.5 年的干预，向村里所有妇女传授了润湿方法，她们欣然接受。木薯粉的总氰化物含量降至 10ppm 以下。用处理过的面粉制作的福福口感和储存效果都比未处理过的面粉好。100 名学童的平均尿硫氰酸盐含量从 332 降至 130 微摩尔/升，在干预期间，超过 350 微摩尔/升的样本数量从 26 降至 0。在同样的地区，科佐病首次由特罗利博士于 1938 年在波波卡巴卡卫生区发现，现在首次得到了预防。该方法现已在博科卫生区使用，我们相信这是控制热带非洲科佐病的最有效方法。
