Markowska A L, Ingram D K, Barnes C A, Spangler E L, Lemken V J, Kametani H, Yee W, Olton D S
Department of Psychology, University of Colorado, Boulder 80309.
Neurobiol Aging. 1990 Sep-Oct;11(5):491-8. doi: 10.1016/0197-4580(90)90109-d.
Three different test sites assessed the effects of acetyl-1-carnitine (AC) on age-related changes in general health, sensory-motor skills, learning, and memory. Two groups of rats began the experiments at 16 months of age. One group (OLD-AC) was given AC, 75 mg/kg/day, beginning at 16 months. The other group (OLD-CON) was treated identically except it was not given the drug. Beginning at 22 months of age, these rats and a group of young (3-4 months old) rats (YG-CON) were given a series of sensory-motor tasks. AC decreased mortality, and had no reliable effect on body weight, fluid intake, or the general health of the rats. These data indicate that a chronic dose of AC does not interfere with food and water intake, and may increase longevity. An age-related decline of performance occurred in most of the sensory-motor tasks; locomotor activity was reduced in a novel environment and in a runwheel, and the ability to prevent falling was reduced in tests on a taut wire, rotorod, inclined screen, and several types of elevated bridges. An age-related decline of performance did not occur in grooming, or in the latency to initiate several different behaviors. AC had no effect on performance in any sensory-motor task. These data indicate that the improvements produced by AC in some tests of spatial memory may be due to the effects of AC on cognitive abilities rather than on sensory-motor skills.
三个不同的试验地点评估了乙酰左旋肉碱（AC）对一般健康、感觉运动技能、学习和记忆方面与年龄相关变化的影响。两组大鼠在16个月大时开始实验。一组（OLD-AC）从16个月大开始给予AC，剂量为75毫克/千克/天。另一组（OLD-CON）的处理方式相同，只是未给予药物。从22个月大开始，这些大鼠以及一组年轻（3 - 4个月大）的大鼠（YG-CON）接受了一系列感觉运动任务测试。AC降低了死亡率，对大鼠的体重、液体摄入量或总体健康状况没有可靠影响。这些数据表明，长期服用AC不会干扰食物和水的摄入，并且可能延长寿命。在大多数感觉运动任务中都出现了与年龄相关的表现下降；在新环境和转轮中运动活动减少，在紧拉的钢丝、转棒、倾斜屏幕和几种类型的高架桥上进行测试时防止跌倒的能力下降。在梳理毛发或启动几种不同行为的潜伏期方面未出现与年龄相关的表现下降。AC对任何感觉运动任务的表现均无影响。这些数据表明，AC在某些空间记忆测试中产生的改善可能是由于AC对认知能力而非感觉运动技能的影响。
