Barnes C A, Markowska A L, Ingram D K, Kametani H, Spangler E L, Lemken V J, Olton D S
Department of Psychology, University of Colorado, Boulder 80309.
Neurobiol Aging. 1990 Sep-Oct;11(5):499-506. doi: 10.1016/0197-4580(90)90110-l.
Acetyl-1-carnitine (AC) was administered via drinking water for six months to one group (OLD-AC) of male F-344 rats beginning at 16 months of age, while another group (OLD-CON) of rats was given water only during that period. The rats were maintained on this treatment throughout behavioral testing, which began at 22 months of age. Performance of the OLD-AC and OLD-CON rats was compared to that of young control (YG-CON) rats on the following set of tasks: spontaneous alternation in the arms of a T-maze, two-choice simultaneous discrimination in the stem of a T-maze, rewarded alternation in the arms of a T-maze, spatial discrimination and reversal on a circular platform, spatial working memory in the radial 8-arm maze, long-term memory in the 14-unit T-maze, and for preference of the light or dark chamber of a two-compartment box. AC improved the long-term memory performance in the split-stem T-maze and on the circular platform but had no discernable effects on performance of aged rats in the other tasks. Possible reasons for the selectivity of this agent's action on behavior are suggested.
从16个月大开始，一组雄性F-344大鼠（OLD-AC组）通过饮用水给予乙酰左旋肉碱（AC），为期6个月，而另一组大鼠（OLD-CON组）在此期间仅给予水。在整个行为测试期间（从22个月大开始），大鼠一直维持这种处理。将OLD-AC组和OLD-CON组大鼠的表现与年轻对照（YG-CON）大鼠在以下一组任务中的表现进行比较：T型迷宫臂中的自发交替、T型迷宫干中的二选一同时辨别、T型迷宫臂中的奖励交替、圆形平台上的空间辨别和逆转、放射状8臂迷宫中的空间工作记忆、14单元T型迷宫中的长期记忆以及对双隔箱明暗室的偏好。AC改善了分裂干T型迷宫和圆形平台上的长期记忆表现，但对老年大鼠在其他任务中的表现没有明显影响。文中提出了该药物行为作用选择性的可能原因。
