Malawi-Liverpool-Wellcome Clinical Research Programme, PO Box 30096, Chichiri, Blantyre 3, Malawi.
Microbes Infect. 2012 Jul;14(7-8):573-83. doi: 10.1016/j.micinf.2012.01.012. Epub 2012 Feb 4.
Multi drug resistant Streptococcus pneumoniae constitute a major public health concern worldwide. In this review we discuss how the transformable nature of the pneumococcus, in parallel with antimicrobial induced stress, contributes to the evolution of antimicrobial resistance; and how the introduction of the pneumococcal conjugate vaccine has affected the situation.
耐多药肺炎链球菌是全球主要的公共卫生关注点。在这篇综述中,我们讨论了肺炎链球菌的可转化特性,以及与抗菌药物诱导的应激并行,如何促进抗菌药物耐药性的演变;以及肺炎球菌结合疫苗的引入如何影响了这一情况。