International School of Public Health, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy of Fez, University Sidi Mohamed Ben Abdellah, Km 2.2 Rte Sidi Harazem, B.P 1893, Fez, Morocco.
BMC Infect Dis. 2022 May 7;22(1):438. doi: 10.1186/s12879-022-07412-4.
Monitoring of antimicrobial resistance (AMR) is of great importance due to the frequency of strains becoming increasingly resistant to antibiotics. This review, using a public health focused approach, which aims to understand and describe the current status of AMR in Morocco in relation to WHO priority pathogens and treatment guidelines.
PubMed, ScienceDirect and Google Scholar Databases and grey literature are searched published articles on antimicrobial drug resistance data for GLASS priority pathogens isolated from Morocco between January 2011 and December 2021. Articles are screened using strict inclusion/exclusion criteria. AMR data is extracted with medians and IQR of resistance rates.
Forty-nine articles are included in the final analysis. The most reported bacterium is Escherichia coli with median resistance rates of 90.9%, 64.0%, and 56.0%, for amoxicillin, amoxicillin-clavulanic acid, and co-trimoxazole, respectively. Colistin had the lowest median resistance with 0.1%. A median resistance of 63.0% is calculated for amoxicillin-clavulanic acid in Klebsiella pneumonia. Imipenem resistance with a median of 74.5% is reported for Acinetobacter baumannii. AMR data for Streptococcus pneumonie does not exceed 50.0% as a median.
Whilst resistance rates are high for most of GLASS pathogens, there are deficient data to draw vigorous conclusions about the current status AMR in Morocco. The recently join to the GLASS system surveillance will begin to address this data gap.
由于菌株对抗生素的耐药性越来越频繁，因此监测抗菌药物耐药性（AMR）非常重要。本综述采用以公共卫生为重点的方法，旨在了解和描述摩洛哥 AMR 的现状，涉及世界卫生组织（WHO）优先病原体和治疗指南。
检索了 PubMed、ScienceDirect 和 Google Scholar 数据库以及灰色文献中发表的有关 2011 年 1 月至 2021 年 12 月从摩洛哥分离的 GLASS 优先病原体的抗菌药物耐药性数据的文章。使用严格的纳入/排除标准筛选文章。提取 AMR 数据，以耐药率的中位数和 IQR 表示。
最终有 49 篇文章纳入了分析。报告最多的细菌是大肠埃希菌，其对阿莫西林、阿莫西林-克拉维酸和复方磺胺甲噁唑的耐药率中位数分别为 90.9%、64.0%和 56.0%。多粘菌素的耐药率中位数最低，为 0.1%。肺炎克雷伯菌对阿莫西林-克拉维酸的耐药率中位数为 63.0%。鲍曼不动杆菌对亚胺培南的耐药率中位数为 74.5%。肺炎链球菌的 AMR 数据中位数不超过 50.0%。
虽然 GLASS 病原体的大多数耐药率较高，但缺乏关于摩洛哥 AMR 现状的有力数据。最近加入 GLASS 系统监测将开始填补这一数据空白。
