Mokry M, Flaschka G, Kleinert G, Kleinert R, Fazekas F, Kopp W
Department of Neurosurgery, University of Graz, Austria.
Neurosurgery. 1990 Sep;27(3):446-51. doi: 10.1097/00006123-199009000-00018.
Expansive granulomatous lesions in the posterior cranial fossa are rare and have not been reported in conjunction with Lyme disease. We report a patient with verified Borrelia burgdorferi infection who developed a tumor in the cerebellopontine angle. Rapid growth of the tumor led to signs of cerebral compression and to hydrocephalus. Surgical intervention was required despite florid meningitis. The histological examination showed inflammatory, nonspecific granulation tissue. The origin of this tissue is almost certainly causally related to the B. burgdorferi infection. Signs of inflammation resolved rapidly after subtotal resection. The clinical, radiological, and biochemical course is documented. This is the first report of an expansive cerebral lesion in the chronic phase of Lyme disease.
后颅窝的广泛性肉芽肿性病变较为罕见，且尚未见与莱姆病相关的报道。我们报告一例经证实感染伯氏疏螺旋体的患者，其在小脑脑桥角出现了一个肿瘤。肿瘤的快速生长导致了脑受压体征和脑积水。尽管存在明显的脑膜炎，仍需要进行手术干预。组织学检查显示为炎症性、非特异性肉芽组织。该组织的起源几乎肯定与伯氏疏螺旋体感染存在因果关系。次全切除术后炎症体征迅速消退。记录了临床、放射学和生物化学过程。这是莱姆病慢性期出现广泛性脑病变的首例报告。
