Department of Plastic Surgery, University of Pavia - IRCCS Fondazione S. Maugeri, Pavia, Italy.
Int J Mol Med. 2012 May;29(5):732-40. doi: 10.3892/ijmm.2012.917. Epub 2012 Feb 15.
An experimental study was carried out in an animal (New Zealand white rabbit) wound model to evaluate any effects of a hypotonic, bicarbonate-calcium-magnesium mineral water (Comano thermal water) on skin regeneration, comparing the healing rate of split-thickness skin graft donor sites treated with the thermal water wet dressing versus a standard petrolatum gauze dressing versus a saline solution wet dressing. The study was performed in two steps; an overall of 22 animals were enrolled in the study. The wound healing progress was evaluated both by the surgeons and by the histologists. Sixty-four punch biopsies were examined in all. The histological samples were examined after staining with haematoxylin and eosin, Masson's and orcein staining and under a transmission electron microscope. The data were statistically analysed. The Comano thermal water proved to improve skin regeneration, not only by increasing keratinocyte proliferation and migration but also favourably modulating the regenerated collagen and elastic fibres in the dermis. We propose that the results of the topical treatment with the thermal water could be due to the favourable combination of a local wet environment with an anti-inflammatory action and that the regenerative properties of Comano thermal water observed in rabbits could also be applied for human use.
一项在动物（新西兰白兔）创伤模型中进行的实验研究旨在评估低张碳酸氢盐钙镁矿泉水（科马诺温泉水）对皮肤再生的任何影响，比较用温泉水湿敷料处理的断层皮片供体部位的愈合率与标准凡士林纱布敷料和生理盐水湿敷料。该研究分两步进行；共有 22 只动物入组。由外科医生和组织学家评估伤口愈合进展情况。总共检查了 64 个活检标本。用苏木精和伊红、马松和地衣红染色以及透射电子显微镜检查组织学样本。对数据进行了统计学分析。科马诺温泉水被证明可以改善皮肤再生，不仅可以增加角质形成细胞的增殖和迁移，而且还可以有利地调节真皮中的再生胶原和弹性纤维。我们提出，温泉水局部治疗的结果可能是由于局部湿润环境与抗炎作用的有利结合，并且在兔子中观察到的科马诺温泉水的再生特性也可用于人类。
