García-Villén Fátima, Faccendini Angela, Miele Dalila, Ruggeri Marco, Sánchez-Espejo Rita, Borrego-Sánchez Ana, Cerezo Pilar, Rossi Silvia, Viseras César, Sandri Giuseppina
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus of Cartuja, 18071 s/n Granada, Spain.
Department of Drug Sciences, Faculty of Pharmacy, University of Pavia, Taramelli Street 12, 27100 Pavia, Italy.
Pharmaceutics. 2020 May 21;12(5):467. doi: 10.3390/pharmaceutics12050467.
hydrogels prepared with natural inorganic excipients and spring waters are commonly used in medical hydrology. Design of these clay-based formulations continues to be a field scarcely addressed. Safety and wound healing properties of different fibrous nanoclay/spring water hydrogels were addressed.
in vitro biocompatibility, by means of MTT assay, and wound healing properties were studied. Confocal Laser Scanning Microscopy was used to study the morphology of fibroblasts during the wound healing process.
all the ingredients demonstrated to be biocompatible towards fibroblasts. Particularly, the formulation of nanoclays as hydrogels improved biocompatibility with respect to powder samples at the same concentration. Spring waters and hydrogels were even able to promote in vitro fibroblasts motility and, therefore, accelerate wound healing with respect to the control.
fibrous nanoclay/spring water hydrogels proved to be skin-biocompatible and to possess a high potential as wound healing formulations. Moreover, these results open new prospects for these ingredients to be used in new therapeutic or cosmetic formulations.
用天然无机辅料和泉水制备的水凝胶常用于医用水文学。这些基于粘土的配方设计仍然是一个几乎未被涉及的领域。研究了不同纤维状纳米粘土/泉水水凝胶的安全性和伤口愈合特性。
通过MTT法研究体外生物相容性，并研究伤口愈合特性。使用共聚焦激光扫描显微镜研究伤口愈合过程中成纤维细胞的形态。
所有成分对成纤维细胞均表现出生物相容性。特别地，在相同浓度下，纳米粘土作为水凝胶的配方相对于粉末样品提高了生物相容性。泉水和水凝胶甚至能够促进体外成纤维细胞的运动，因此相对于对照加速伤口愈合。
纤维状纳米粘土/泉水水凝胶被证明对皮肤具有生物相容性，并具有作为伤口愈合配方的巨大潜力。此外，这些结果为这些成分用于新的治疗或化妆品配方开辟了新的前景。
