将非化学应激源纳入累积风险评估中。
Incorporating nonchemical stressors into cumulative risk assessments.
机构信息
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
出版信息
Toxicol Sci. 2012 May;127(1):10-7. doi: 10.1093/toxsci/kfs088. Epub 2012 Feb 17.
Abstract
The role of nonchemical stressors in modulating the human health risk associated with chemical exposures is an area of increasing attention. On 9 March 2011, a workshop titled "Approaches for Incorporating Nonchemical Stressors into Cumulative Risk Assessment" took place during the 50th Anniversary Annual Society of Toxicology Meeting in Washington D.C. Objectives of the workshop included describing the current state of the science from various perspectives (i.e., regulatory, exposure, modeling, and risk assessment) and presenting expert opinions on currently available methods for incorporating nonchemical stressors into cumulative risk assessments. Herein, distinct frameworks for characterizing exposure to, joint effects of, and risk associated with chemical and nonchemical stressors are discussed.
摘要
非化学应激源在调节与化学暴露相关的人类健康风险中的作用是一个日益受到关注的领域。2011 年 3 月 9 日，在华盛顿特区举行的第 50 届毒理学学会年会期间举办了一次题为“将非化学应激源纳入累积风险评估的方法”的研讨会。该研讨会的目的包括从不同角度（即监管、暴露、建模和风险评估）描述当前的科学现状，并就目前将非化学应激源纳入累积风险评估的现有方法提出专家意见。本文讨论了化学和非化学应激源的暴露、联合效应和风险特征的不同框架。
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