CNRS, Unit of Virus Host Cell Interaction, Grenoble, France.
J Virol. 2012 May;86(9):5380-5. doi: 10.1128/JVI.07127-11. Epub 2012 Feb 15.
During human adenovirus type 3 (Ad3) infection, an excess of penton base and fiber proteins are produced which form dodecahedral particles composed of 12 pentamers of penton base and 12 trimers of fiber protein. No biological functions have yet been ascribed to Ad3 dodecahedra. Here, we show that dodecahedra compete with Ad3 virions for binding to the cell surface and trigger cell remodeling, giving new insights into possible biological functions of dodecahedra in the Ad3 infectious cycle.
在人类腺病毒 3 型（Ad3）感染期间，会产生过量的五邻体基底和纤维蛋白，它们形成由 12 个五邻体基底五聚体和 12 个纤维蛋白三聚体组成的十二面体颗粒。目前尚未确定 Ad3 十二面体的生物学功能。在这里，我们表明十二面体与 Ad3 病毒颗粒竞争与细胞表面结合，并引发细胞重塑，为 Ad3 感染周期中十二面体的可能生物学功能提供了新的见解。
