Department of Medical Oncology, Kayseri Training and Research Hospital, Kayseri, Turkey.
Clin Appl Thromb Hemost. 2013 Jun;19(3):331-3. doi: 10.1177/1076029611433644. Epub 2012 Feb 16.
Mean platelet volume (MPV) is an indicator of thrombocyte volume and tendency to thrombosis can be mentioned in case of MPV elevation. Cancers are one of the important groups of thrombotic diseases. In the present study, MPV value was scrutinized in patients with cancer that developed thrombosis. Totally 43 patients followed in Kayseri Training and Research Hospital, in who thromboembolus has been developed, were prospectively recruited in the study. Thrombocyte, MPV, and platicrit (PCT) values were recorded at the time of cancer diagnosis and thrombosis development. Frequency analysis, crosstabs, and paired samples t test were used. Analyses showed that MPV values at the time of thrombosis development were significantly low as compared to those at the time of cancer diagnosis (P = .041). Thrombocyte count and PCT values were also low but not significant. The result of the present study is likely to show that thrombocytes have ignorable effect on thrombosis development in patients with cancer.
平均血小板体积（MPV）是血小板体积的指标，MPV 升高可提示血栓形成倾向。癌症是血栓性疾病的重要类别之一。在本研究中，我们对发生血栓形成的癌症患者的 MPV 值进行了研究。前瞻性招募了在开塞利培训和研究医院就诊的 43 例血栓栓塞患者。在诊断癌症和发生血栓形成时，记录血小板、MPV 和血小板蛋白 C （PCT）值。采用频率分析、交叉表和配对样本 t 检验进行分析。分析表明，与诊断癌症时相比，发生血栓时的 MPV 值显著降低（P =.041）。血小板计数和 PCT 值也较低，但无统计学意义。本研究结果可能表明，癌症患者的血小板对血栓形成的发展影响不大。
