Department of Surgery, Conrad Jobst Vascular Research Laboratories, University of Michigan, A570 MSRB II, Dock #6, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0654, USA.
Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):556-62. doi: 10.1161/ATVBAHA.111.244608.
Deep vein thrombosis and pulmonary embolism are a significant health care concern, representing a major source of mortality and morbidity. In order to understand the pathophysiology of thrombogenesis and thrombus resolution, animal models are necessary. Mouse models of venous thrombosis contribute to our understanding of the initiation, propagation, and resolution of venous thrombus, as well as allow for the evaluation of new pharmaceutical approaches to prophylaxis and treatment of deep vein thrombosis. In this work we review the ferric chloride model, the inferior vena cava ligation model, the inferior vena cava stenosis models, and the electrolytic inferior vena cava model and compare their advantages and disadvantages.
深静脉血栓形成和肺栓塞是一个重大的医疗保健问题，是导致死亡率和发病率的主要原因。为了了解血栓形成和血栓溶解的病理生理学，需要动物模型。静脉血栓形成的小鼠模型有助于我们理解静脉血栓形成的起始、传播和溶解，也允许评估预防和治疗深静脉血栓形成的新药物方法。在这项工作中，我们回顾了三氯化铁模型、下腔静脉结扎模型、下腔静脉狭窄模型和电解下腔静脉模型，并比较了它们的优缺点。
