Bhatt Taseer Ahmed, Fatani Hanadi A, Mimesh Samara
Department of Internal Medicine, Dermatology Division, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia .
Indian J Dermatol. 2011 Nov;56(6):734-6. doi: 10.4103/0019-5154.91841.
Neonatal lupus erythematosus (NLE) is an autoimmune disease affecting the fetus as a result of transplacental transfer of anti-Ro autoantibodies. Typically, it presents in the first few months of life with an annular form of subacute cutaneous lupus erythematosus. We report an unusual case of NLE presenting at birth with scaly erythematous telangiectatic patches and macules with skin atrophy involving the face, head, and upper trunk. Thrombocytopenia was discovered on laboratory investigations. Histopathology of skin biopsy was consistent with subacute cutaneous lupus. The mother was clinically free of disease and had no family history of autoimmune disease. Serology (extra-nuclear antigens) was positive in both the baby and the mother. This is a rare presentation of a rare disease.
新生儿红斑狼疮（NLE）是一种由于抗Ro自身抗体经胎盘转移而影响胎儿的自身免疫性疾病。通常，它在出生后的头几个月表现为环形亚急性皮肤型红斑狼疮。我们报告了一例不寻常的NLE病例，患儿出生时即出现鳞屑性红斑性毛细血管扩张斑和斑疹，伴有面部、头部和上躯干皮肤萎缩。实验室检查发现血小板减少。皮肤活检的组织病理学与亚急性皮肤型狼疮一致。母亲临床无疾病，且无自身免疫性疾病家族史。婴儿和母亲的血清学（核外抗原）均为阳性。这是一种罕见疾病的罕见表现。
