Mattern C F, Keister D B, Diamond L S
Am J Trop Med Hyg. 1979 Jul;28(4):653-7.
We have attempted to determine whether amebal viruses are capable of viral conversion of the virulence of Entamoeba histolytical. Amebae of little or no virulence for the newborn hamster liver were infected with viruses obtained from four amebal strains of different virulence. Cultures of surviving amebae were increased in virulence by viruses from amebae of high, moderate, or low virulence, but decreased in virulence by the virus of the second most pathogenic amebal strain. Sequential infection with two viruses did not produce consistent cumulative effects on virulence. The changes in virulence noted are considered to be the unpredictable result of either selection pressures exerted by the lytic virus infection or possibly viral alterations of the amebae.
我们试图确定阿米巴病毒是否能够对溶组织内阿米巴的毒力进行病毒转化。对新生仓鼠肝脏几乎没有毒力或无毒力的阿米巴，用从四种不同毒力的阿米巴菌株获得的病毒进行感染。存活阿米巴的培养物，其毒力会因来自高毒力、中等毒力或低毒力阿米巴的病毒而增加，但会因第二致病力最强的阿米巴菌株的病毒而降低。用两种病毒进行连续感染，并未对毒力产生一致的累积效应。所观察到的毒力变化被认为是由裂解性病毒感染施加的选择压力的不可预测结果，或者可能是阿米巴的病毒改变的结果。
