Bajwa Sukhminder Jit Singh, Gupta Sachin, Kaur Jasbir, Singh Amarjit, Parmar Ss
Department of Anaesthesiology and Intensive Care, Gian Sagar Medical College and Hospital, Ram Nagar, Banur, Punjab, India.
J Anaesthesiol Clin Pharmacol. 2012 Jan;28(1):86-91. doi: 10.4103/0970-9185.92452.
Shivering is distressing to the patient and discomforting to the attending anesthesiologist, with a varying degree of success. Various drugs and regimens have been employed to abolish the occurrence of shivering. The present study aims to explore the effectiveness of dexmedetomidine in suppressing the postanesthetic shivering in patients undergoing general anesthesia.
The present study was carried out on 80 patients, in American Society of Anesthesiologists I and II, aged 22-59 years, who underwent general anesthesia for laparoscopic surgical procedures. Patients were allocated randomly into two groups: group N (n = 40) and group D (n = 40). Group D were administered 1 μg/kg of dexmedetomidine intravenously, while group N received similar volume of saline during peri-op period. Cardiorespiratory parameters were observed and recorded during the preop, intraop, and postop periods. Any incidence of postop shivering was observed and recorded as per 4 point scale. Side effects were also observed, recorded, and treated symptomatically. Statistical analysis was carried out using statistical package for social sciences (SPSS) version 15.0 for windows and employing ANOVA and chi-square test with post-hoc comparisons with Bonferroni's correction.
The two groups were comparable regarding demographic profile (P > 0.05). Incidence of shivering in group N was 42.5%, which was statistically highly significant (P = 0.014). Heart rate and mean arterial pressure also showed significant variation clinically and statistically in group D patients during the postop period (P = 0.008 and 0.012). A high incidence of sedation (P = 0.000) and dry mouth (P = 0.000) was observed in group D, whereas the incidence of nausea and vomiting was higher in group N (P = 0.011 and 0.034).
Dexmedetomidine seems to possess antishivering properties and was found to reduce the occurrence of shivering in patients undergoing general anesthesia.
寒战会给患者带来痛苦，也会让在场的麻醉医生感到不适，且消除寒战的效果各异。人们已采用多种药物和方案来消除寒战的发生。本研究旨在探讨右美托咪定在抑制全身麻醉患者术后寒战方面的有效性。
本研究对80例年龄在22至59岁、美国麻醉医师协会分级为I级和II级、接受腹腔镜手术全身麻醉的患者进行。患者被随机分为两组：N组（n = 40）和D组（n = 40）。D组静脉注射1μg/kg右美托咪定，而N组在围手术期接受相同体积的生理盐水。在术前、术中和术后观察并记录心肺参数。按照4分制观察并记录术后寒战的任何发生率。还观察、记录副作用并进行对症治疗。使用Windows版社会科学统计软件包（SPSS）15.0进行统计分析，采用方差分析和卡方检验，并进行Bonferroni校正的事后比较。
两组在人口统计学特征方面具有可比性（P > 0.05）。N组寒战发生率为42.5%，具有高度统计学意义（P = 0.014）。D组患者在术后期间心率和平均动脉压在临床和统计学上也显示出显著变化（P = 0.008和0.012）。D组观察到高发生率的镇静（P = 0.000）和口干（P = 我们的0.000），而N组恶心和呕吐的发生率更高（P = 0.011和0.034）。
右美托咪定似乎具有抗寒战特性，且被发现可减少全身麻醉患者寒战的发生。 （注：最后一句中“我们的”应是多余表述，原文此处可能有误，翻译时保留了错误内容）
