植物穿心莲的抗眼镜蛇毒活性及其与多价抗蛇毒血清的比较。
Anti-cobra venom activity of plant Andrographis paniculata and its comparison with polyvalent anti-snake venom.
作者信息
Premendran S Jhon, Salwe Kartik J, Pathak Swanand, Brahmane Ranjana, Manimekalai K
机构信息
Department of Pharmacology, Mamata Medical College, Khammam, Andhra Pradesh, India.
出版信息
J Nat Sci Biol Med. 2011 Jul;2(2):198-204. doi: 10.4103/0976-9668.92326.
BACKGROUND
To investigate the anti-cobra venom effect of alcoholic extract of Andrographis paniculata.
MATERIALS AND METHODS
After calculating the LD(99) of snake venom, the venom-neutralizing ability of plant extract at the dose 1 g/kg and 2 g/kg was determined using in vitro and in vivo methods. The alleviation in the mean survival time of the animals were used to infer the antivenom property of the drug after challenging with LD(99) of snake venom.
RESULTS
The ethanolic extract of plant A. paniculata significantly increases mean survival time and the protection fold, but could not protect animals from death when used alone. The higher dose, i.e., 2 g/kg was found better than that of the lower. ASV was found more effective than the plant extract. When ASV was given along with plant extract, it potentiates its effect.
CONCLUSION
The observation demonstrates the anti-cobra venom activity of ethanolic extract of A. paniculata which is comparable with ASV.
背景
研究穿心莲乙醇提取物的抗眼镜蛇毒作用。
材料与方法
计算蛇毒的LD(99)后，采用体外和体内方法测定1 g/kg和2 g/kg剂量植物提取物的毒液中和能力。用蛇毒LD(99)攻击动物后，通过动物平均存活时间的延长来推断药物的抗蛇毒特性。
结果
穿心莲乙醇提取物显著延长平均存活时间和保护倍数，但单独使用时不能保护动物免于死亡。发现较高剂量（即2 g/kg）比较低剂量效果更好。抗蛇毒血清（ASV）比植物提取物更有效。当ASV与植物提取物一起给药时，可增强其效果。
结论
该观察结果证明了穿心莲乙醇提取物具有抗眼镜蛇毒活性，与抗蛇毒血清相当。
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