Odendaal H J, Pattinson R C, Bam R, Grove D, Kotze T J
Department of Obstetrics and Gynecology, University of Stellenbosch, Tygerberg, South Africa.
Obstet Gynecol. 1990 Dec;76(6):1070-5.
Fifty-eight women with severe preeclampsia between 28-34 weeks' gestation qualified for a randomized controlled trial to establish whether elective delivery 48 hours after administration of betamethasone (aggressive-management group) or delivery later as indicated by maternal or fetal condition (expectant-management group) was more beneficial to maternal and fetal outcome. Twenty women who qualified were not randomized because they developed maternal or fetal indications necessitating delivery within 48 hours; these newborns developed most of the complications. Expectant management was not associated with an increase in maternal complications, but it significantly prolonged the gestational age (mean 7.1 days; P less than .05), reduced the number of neonates requiring ventilation (P less than .05), and reduced the number of neonatal complications (P less than .05).
58名孕28 - 34周的重度子痫前期女性符合一项随机对照试验的条件，该试验旨在确定在给予倍他米松后48小时进行择期分娩（积极管理组）还是根据母体或胎儿状况适时延迟分娩（期待管理组）对母婴结局更有益。20名符合条件的女性未被随机分组，因为她们出现了母体或胎儿指征，需要在48小时内分娩；这些新生儿出现了大多数并发症。期待管理与母体并发症增加无关，但显著延长了孕周（平均7.1天；P<0.05），减少了需要通气的新生儿数量（P<0.05），并减少了新生儿并发症的数量（P<0.05）。
