导航引导下内镜活检用于脑室三角区附近脑实质内纯生殖细胞瘤的病理诊断。

Navigation-guided endoscopic biopsy for pathological diagnosis for intraparenchymal pure germinoma near the ventricular trigone.

作者信息

Onuma Kuniyuki, Ishikawa Eiichi, Matsuda Masahide, Shibata Yasushi, Satomi Kaishi, Yamamoto Tetsuya, Zaboronok Alexander, Takano Shingo, Matsumura Akira

机构信息

Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

出版信息

Surg Neurol Int. 2012;3:9. doi: 10.4103/2152-7806.92177. Epub 2012 Jan 21.

DOI:10.4103/2152-7806.92177

PMID:22347677

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3279989/

Abstract

BACKGROUND

The authors report a case of intraparenchymal germinoma pathologically diagnosed using navigation-guided endoscopic biopsy.

CASE DESCRIPTION

A 27-year-old man had mild left hemiparesis, transcortical motor aphasia, and amnesia. Magnetic resonance (MR) imaging revealed an intraparenchymal mass lesion near the left ventricular trigone. Navigation-guided endoscopic biopsy was performed, and histopathology revealed large neoplastic cells immunohistochemically positive for germinoma-specific antigens, which were diagnosed as pure germinoma. Chemotherapy with whole-brain radiotherapy was performed, and the neurological symptoms did not change during the treatment. Follow-up MR imaging 1 year after the surgery showed no evidence of recurrence or dissemination.

CONCLUSIONS

Navigation-guided endoscopic biopsy can be a useful technique in such intraparenchymal germinoma cases.

摘要

背景

作者报告了一例经导航引导下内镜活检病理诊断为脑实质内生殖细胞瘤的病例。

病例描述

一名27岁男性出现轻度左侧偏瘫、经皮质运动性失语和失忆。磁共振成像显示左心室三角区附近有一个脑实质内肿块病变。进行了导航引导下内镜活检，组织病理学显示大的肿瘤细胞免疫组化对生殖细胞瘤特异性抗原呈阳性，诊断为纯生殖细胞瘤。采用全脑放疗进行化疗，治疗期间神经症状未改变。术后1年的随访磁共振成像显示无复发或播散迹象。