Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Biochemistry (Mosc). 2012 Feb;77(2):187-93. doi: 10.1134/S0006297912020101.
The fatty acid composition of thymus cells, liver, blood plasma, muscle tissue, and tumor focus has been studied in mice with solid Ehrlich carcinoma. The tumor growth in the mice was associated with an increase in the total content of monounsaturated fatty acids in all organs and tissues studied and with a decrease in the total amount of polyunsaturated fatty acids in all tissues except blood plasma. The tumor tissue was characterized by increased levels of monounsaturated fatty acids in comparison with their levels in organs and tissues of intact animals. In the thymus of tumor-bearing mice, the contents of myristic and palmitic saturated fatty acids, which are associated with activation of the T-cell immunity, were increased. The most expressed and considerable changes in the fatty acid composition during tumor growth were observed in the muscle tissue of the animals. A possible role of changes in the fatty acid composition in the investigated organs and tissues of tumor-bearing mice in the organism's response to tumor growth is discussed.
研究了患有实体型艾利希腹水癌的小鼠的胸腺细胞、肝脏、血浆、肌肉组织和肿瘤病灶的脂肪酸组成。肿瘤在小鼠体内的生长与所有研究的器官和组织中单不饱和脂肪酸的总含量增加有关，与除血浆外所有组织中多不饱和脂肪酸的总量减少有关。与完整动物器官和组织中的水平相比，肿瘤组织的单不饱和脂肪酸水平更高。在荷瘤小鼠的胸腺中，与 T 细胞免疫激活相关的饱和脂肪酸肉豆蔻酸和棕榈酸的含量增加。在肿瘤生长过程中，脂肪酸组成的变化在动物的肌肉组织中最为明显和显著。讨论了荷瘤小鼠的这些器官和组织中脂肪酸组成的变化在机体对肿瘤生长的反应中的可能作用。
