Ygge J, Wenzel M, Philipson B, Fagerholm P
Department of Ophthalmology, Karolinska Institutet, Huddinge Hospital, Sweden.
Ophthalmology. 1990 Sep;97(9):1216-23; discussion 1223-4. doi: 10.1016/s0161-6420(90)32433-8.
Specular microscopy was used for investigation of cellular reactions on the intraocular lens (IOL) anterior surface of Heparin surface-modified (HSM) versus regular polymethylmethacrylate (PMMA) lenses (Pharmacia types 700C versus 700B, respectively). The double-masked randomized study included 53 patients investigated at 1 and 4 weeks postoperatively. Giant cells were only found on control lenses and more frequently at 4 weeks. Small cells were found on both lens types, but in a higher frequency on the control lenses. The number of small cells decreased during the first 4 weeks on both the control and HSM lenses. However, those control lenses that had giant cells on their surface showed an increase in the number of small cells during the same time. The results of the current study show that HSM lenses give rise to less postoperative inflammatory cellular reactions than regular PMMA lenses.
采用镜面显微镜检查法，对肝素表面修饰（HSM）人工晶状体（IOL）与普通聚甲基丙烯酸甲酯（PMMA）晶状体（分别为法玛西亚700C型和700B型）前表面的细胞反应进行研究。这项双盲随机研究纳入了53例患者，在术后1周和4周进行检查。仅在对照晶状体上发现巨细胞，且在4周时更为常见。在两种类型的晶状体上均发现了小细胞，但对照晶状体上的小细胞频率更高。在对照晶状体和HSM晶状体上，小细胞数量在最初4周内均有所减少。然而，那些表面有巨细胞的对照晶状体在同一时期小细胞数量有所增加。当前研究结果表明，与普通PMMA晶状体相比，HSM晶状体引起的术后炎症细胞反应更少。
